Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus |
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| Authors: | Feng-Yu Du Xiao-Ming Li Peng Zhang Chun-Shun Li Bin-Gui Wang |
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| Institution: | 1.College of Chemistry & Pharmacy, Qingdao Agricultural University, Qingdao 266109, China; E-Mail: ;2.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; E-Mails: (X.-M.L.); (P.Z.); (C.-S.L.) |
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| Abstract: | Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (4–7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality. |
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| Keywords: | marine fungus bryozoan Beauveria felina secondary metabolites bioactivity |
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