| 治疗鸡大肠杆菌病的中药方剂筛选 |
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| 引用本文： | 贺常亮,韦旭斌,付本懂,蒋小林,吕程,张伟,伊鹏霏,申海清.治疗鸡大肠杆菌病的中药方剂筛选[J].兽医大学学报,2013(12):1917-1922. |
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| 作者姓名： | 贺常亮 韦旭斌 付本懂 蒋小林 吕程 张伟 伊鹏霏 申海清 |
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| 作者单位： | [1]四川农业大学动物医学学院药学系,四川雅安625014 [2]吉林大学畜牧兽医学院临床兽医学系,吉林长春130062 |
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| 基金项目： | 基金项目：“十一五”国家科技支撑计划（2008BADB4804-4）;吉林大学农学部博士科研启动基金项目 |
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| 摘 要： | 为了获得有较好疗效的治疗鸡大肠杆菌病的中药复方，基于中兽医学理论拟定了39个备选方剂。利用建立的人工感染鸡大肠杆菌病病理模型，对39个备选方剂进行了筛选，发现方4、5、24与26的效果较好，病死率分别是30％、40％、26．7％、26．7％，攻毒对照组的死亡率为80％。为了进一步确证这些方剂的有效性，对方4、5、24、26进行了2次重复试验，结果显示4个方剂效果稳定，对试验性鸡大肠杆菌病均有较好的治疗效果，病死率在46．7％以下。相比之下，26号方效果最好，2次重复试验死亡率均为26．7％。通过正交试验对26号方组成药物的用量进行了筛选，确定其最佳配比为香附40g，穿心莲30g、黄芪30g，并将该方命名为“香芪汤”，为有效治疗鸡大肠杆菌病提供了理论基础。
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| 关 键 词： | 鸡大肠杆菌病 中药 筛选 |
Screening of Chinese medical formula for curing chicken colibacillosis |
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| Authors: | HE Chang-liang WEI Xu-bin FU Ben-dong JIANG Xiao-lin LYu Cheng ZHANG Wei YI Peng-fei SHEN Hai-qing |
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| Institution: | 1. Department of Pharmacy, College of Veterinary Medicine, Si- chuan Agricultural University ,Ya an, Sichuan 625014, China 2. Department of Clinical Veteri- nary Medicine ,College of Animal Science and Veterinary Medicine ,J ilin University ,Changchun 130062, China) |
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| Abstract: | To obtain a Chinese medical formula for Chinese medical formulas through chicken model curing chicken colibacillosis,we had screened 39 infected by APEC. The results showed that No. 4,No. 5 ,No. 24 and NO. 26 had better effect on decreasing the infected chicken mortality,and their mortality were,30%,40%, 26.7% and 26.7%, respectively. To confirm the effects of these Chi- nese medical formulas,we carried out 2 repeated tests and found that they had stable effects on chicken infected by APEC,the mortality were below 46.7%. And No. 26 is the best one of which the mortality was 26.7% in 2 repeated tests. Then we defined the usage of the combined drugs of No. 26,which is Rhizorna Cyperi 40 g,Andrographis paniculata 30 g,Astragalus membranaceus 30 g, and designated it as ＂Xiang-Qi-Tang＂,which play theory fundation for curing chicken colibacillosis. |
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| Keywords: | chicken colibacollosis screen traditional Chinese veterinary medicine |
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