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Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle |
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| Authors: | T Nelson G Lucignani S Atlas A M Crane G A Dienel L Sokoloff |
| Abstract: | Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of 2-3H]glucose and U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain. |
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