| 丹参通络解毒汤对冠心病不稳定型心绞痛患者黏附分子的影响 |
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| 作者姓名： | 李鑫辉 王静雯 肖青 杜建芳 吴若霞 李彩云 徐玛丽 张睿尧 |
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| 作者单位： | 湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208,湖南中医药大学中医学院, 湖南 长沙 410208 |
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| 基金项目： | 国家自然科学基金面上项目（30973750）；湖南省教育厅科学研究研重点项目（15A143）；湖南省中医药科研计划项目（201559）；长沙市科技计划项目（kq1706058）；研究生创新课题（2016cx21）。 |
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| 摘 要： | 目的 观察丹参通络解毒汤对瘀热壅毒、毒损心营证不稳定型心绞痛（unstanble angina，UA）患者的血脂以及血清细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）的影响。方法 选择瘀热壅毒、毒损心营型冠心病不稳定型心绞痛患者60例。将60例患者随机分为两组，对照组30例给予常规西药治疗，观察组30例在对照组治疗基础上加服丹参通络解毒汤治疗，观察两组治疗2个月后的中医证候积分、心电图疗效、心绞痛疗效以及治疗前后血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、ICAM-1和VCAM-1的水平变化。结果 观察后，观察组中医证候积分心电图疗效，心绞痛疗效均较对照组高，差异有统计学意义（P<0.05）。治疗后两组TC、TG、LDL-C、ICAM-1和VCAM-1水平较治疗前降低，HDL-C水平较治疗前增加，且观察组血脂、黏附因子水平改善程度优于对照组，差异有统计学意义（P<0.05）。结论 丹参通络解毒汤治疗瘀热壅毒，毒损心营型冠心病不稳定型心绞痛疗效确切，其作用机制可能与调节血脂代谢、降低ICAM-1和VCAM-1水平有关。
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| 关 键 词： | 丹参通络解毒汤 冠心病不稳定型心绞痛 血清细胞间黏附分子-1 血管细胞黏附分子-1 血脂 |
| 收稿时间： | 2017/10/3 0:00:00 |
Effects of Danshen Tongluo Jiedu Decoction on Adhesion Molecules in Patients with Unstable Coronary Artery Disease |
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| Authors: | LI Xinhui WANG Jingwen XIAO Qing DU Jianfang WU Ruoxi LI Caiyun XU Mali and ZHANG Ruiyao |
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| Institution: | College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China and College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China |
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| Abstract: | Objective To observe the effects of Danshen Tongluo Jiedu decoction on blood lipids, serum intercellular adhesion molecule-1 (ICAM 1) and vascular cell adhesion molecule 1 (VCAM 1) in unstanble angina patients with stagnant heat and toxin and toxin damaging heat-nutrient syndromes.Methods Sixty unstanble angina patients with stagnant heat and toxin and toxin damaging heat-nutrient syndromes were selected. The 60 patients were randomly divided into two groups, 30 cases in each group. The control group was treated with conventional medicine, and the observation group was treated with Danshen Tongluo Jiedu decoction on the basis of control group. The changes of TCM syndrome scores, electrocardiogram, angina, and the levels of TC, TG, HDL-C, LDL-C, ICAM-1 and VCAM-1 were observed after treatment for two months.Results The effects of TCM syndrome scores, electrocardiogram, angina in observation group were higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of TC, TG, LDL-C, ICAM-1 and VCAM-1 after treatment were lower than that before treatment, the level of HDL-C increased, and the improvment of blood lipid and adhere factor levels was better than that of the control group, the differences were statistically significant (P<0.05).Conclusion The effects of Danshen Tongluo Jiedu decoction in treating unstanble angina patients with stagnant heat and toxin and toxin damaging heat-nutrient syndromes were obvious, and its mechanism may be related to the regulation of blood lipid metabolism, reducing ICAM-1 and VCAM-1 levels. |
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| Keywords: | Danshen Tongluo Jiedu decoction unstable coronary artery disease ICAM-1 VCAM-1 blood lipid |
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