Effect of interval between doses on response of the pony to sodium bicarbonate. |
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| Authors: | J Kowalski A Roberts J Williams H F Hintz P Daniluk H F Schryver |
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| Institution: | Department of Animal Science, New York State College of Agriculture, Cornell University, Ithaca 14853. |
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| Abstract: | Three pony geldings were given sodium bicarbonate orally in order to study the effect on blood pH and bicarbonate and to determine if frequency of dosing influences the response. In a preliminary study, it appeared that a carry-over effect might occur if the interval between dosing was only 2 days. The ponies received 2 doses of sodium bicarbonate (400 mg/kg) 7 days apart in trial one and then in trial two they received 2 doses of sodium bicarbonate 4 days apart. The sodium bicarbonate was mixed with 2 liters of warm water and given through a nasogastric tube on each trial day. Blood samples were taken before dosing, and every half hour after for five and a half hours. The blood was analyzed for pH and bicarbonate. There did not seem to be a carry-over effect due to sodium bicarbonate administration since there was little difference in the responses between the first and second doses of each trial. |
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