Dendritic cell-induced memory T cell activation in nonlymphoid tissues |
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| Authors: | Wakim Linda M Waithman Jason van Rooijen Nico Heath William R Carbone Francis R |
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| Institution: | Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia. |
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| Abstract: | Secondary lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen-presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue-resident T cells during secondary challenge. The results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection. |
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