| 用于修复三尖瓣返流的三尖瓣塞离体试验研究 |
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| 引用本文： | 杨梦旭,王颢,荆腾,周中玺,王昆,贺照明.用于修复三尖瓣返流的三尖瓣塞离体试验研究[J].排灌机械工程学报,2020,38(10):1030-1036. |
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| 作者姓名： | 杨梦旭 王颢 荆腾 周中玺 王昆 贺照明 |
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| 作者单位： | 江苏大学国家水泵及系统工程技术研究中心,江苏 镇江 212013;南京医科大学第一附属医院临床医学工程处,江苏 南京 210029;江苏大学国家水泵及系统工程技术研究中心,江苏 镇江 212013;德州理工大学机械工程系,美国 德克萨斯州 拉伯克 79409 |
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| 摘 要： | 研究三尖瓣塞的血流动力学性能并评价其修复效果.使用8个新鲜猪心三尖瓣,安装在离体试验台上,用扩张瓣环50%,75%的方法构建2种三尖瓣反流病理模型.使用3D打印技术打印直径为20,25mm的三尖瓣塞(记为TP20和TP25),分别进行脉动试验和静态试验,测量并分析瓣塞修复前后的跨瓣压差积分、心输出量、反流流量、关闭流量、泄漏流量以及有效孔口面积和有效反流孔口面积.结果表明:三尖瓣在使用瓣塞修复之后,跨瓣压差积分增加30%~100%,反流流量减小42%~47%,有效孔口面积和有效反流孔口面积减小37%~74%,瓣环扩张75%时心输出量增加43%~47%;扩张50%时,使用TP25比TP20修复之后的跨瓣压差积分、有效孔口面积减小9%~26%,每搏反流流量增大29%;扩张75%时使用TP25比TP20修复时有效孔口面积和有效反流孔口面积小15%~17%,其他参数无差异.三尖瓣塞可以有效减少三尖瓣反流;瓣环扩张50%时TP20的修复效果优于TP25,扩张75%时2种瓣塞修复效果没有差异.
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| 关 键 词： | 三尖瓣塞 三尖瓣返流 心脏瓣膜 微创修复 离体试验 |
| 收稿时间： | 2019-03-29 |
Tricuspid plug for functional tricuspid regurgitation: an invitro study |
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| YANG Mengxu,WANG Hao,JING Teng,ZHOU Zhongxi,WANG Kun,HE Zhaoming.Tricuspid plug for functional tricuspid regurgitation: an invitro study[J].Journal of Drainage and Irrigation Machinery Engineering,2020,38(10):1030-1036. |
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| Authors: | YANG Mengxu WANG Hao JING Teng ZHOU Zhongxi WANG Kun HE Zhaoming |
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| Institution: | 1. National Research Center of Pumps, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2. Department of Clincial Medical Engineering, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; 3. Department of Mechanical Engineering, Texas Tech University, Lubbock, Texas 79409, USA |
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| Abstract: | To investigate the hemodynamic performance of tricuspid plugs and evaluate its performance, 8 fresh porcine tricuspid valves were mounted in a right heart simulator to simulate the functional tricuspid regurgitation by two pathological models by 50% and 75% annular dilatation. Two tricuspid plugs in diameters of 20 mm and 25 mm(noted as TP20 and TP25)were made by 3D prin-ter, and separately tested in pulsatile and steady flow experiments. The integral of transvalvular pressure, cardiac output, regurgitation volume, closing volume, leakage volume, forward and regurgitant effective orifice area were measured and analyzed before and after the plug repair. The results show that after the repair of tricuspid valve with plug, the integral of transvalvular pressure improves by 30%-100%, the regurgitation volume reduces by 42%-47%, and the effective orifice area and regurgitant effective orifice area reduce by 37%-74%. The cardiac output increases by 43%-47% under 75% annulus dilation. The integral of transvalvular pressure and the effective orifice area of TP25 is 9%-16% lower and the regurgitation volume is 29% greater than that of TP20 under 50% annulus dilation. The effective orifice area and the regurgitant effective orifice area of TP25 is 15%-17% lower than that of TP20 under 75% annulus dilation, and other data showed no difference. The tricuspid plug is effective to reduce tricuspid regurgitation. The repair effect of TP20 is better than that of TP25 under 50% annulus dilation. There is no difference between the two plugs′ performances under 75% annulus dilation. |
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| Keywords: | tricuspid plug tricuspid regurgitation heart valve minimally invasive repair in vitro experiment |
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