| 鸡亚慢性镉中毒后肝脏镉含量的测定与形态学观察 |
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| 引用本文： | 傅业全,何宝霞,徐世文.鸡亚慢性镉中毒后肝脏镉含量的测定与形态学观察[J].中国农学通报,2007,23(4):1-1. |
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| 作者姓名： | 傅业全 何宝霞 徐世文 |
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| 作者单位： | 东北农业大学动物医学院，东北农业大学动物医学院，东北农业大学动物医学院 哈尔滨，150030，哈尔滨，150030，哈尔滨，150030 |
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| 基金项目： | 黑龙江省教育厅资助项目“氯化镉诱导鸡淋巴细胞凋亡机理的研究”（10551038）. |
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| 摘 要： | 【目的】探讨亚慢性镉中毒鸡肝脏中镉的蓄积情况及显微和超微结构的变化。【方法】将30只50日龄健康海蓝白蛋鸡随机分为3组，对照组饲喂基础日粮，低镉组饲喂基础饲粮+CdCl2140mg/kg，高镉组饲喂基础饲粮+CdCl2210mg/kg，分别在20d、40d、60d取肝脏测定镉含量，并做光镜和电镜观察。【结果】镉在肝中的蓄积量存在时间和剂量效应。加镉组鸡肝细胞发生变性、坏死，细胞内线粒体、内质网等膜性细胞器损害严重。【结论】肝脏是镉重要的靶器官；随着染镉剂量的增加和时间的延长，肝脏的损害越严重。
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| 关 键 词： | 鸡 镉中毒 肝 蓄积 超微结构 |
| 修稿时间： | 2006-12-22 |
Investigation on Determination of Cadmium and Observation of Morphology in Liver of Hyline-white Laying Hens with Subchronic Cadmium Toxication |
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| Fu Yequan,He Baoxi,Xu Shiwen.Investigation on Determination of Cadmium and Observation of Morphology in Liver of Hyline-white Laying Hens with Subchronic Cadmium Toxication[J].Chinese Agricultural Science Bulletin,2007,23(4):1-1. |
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| Authors: | Fu Yequan He Baoxi Xu Shiwen |
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| Institution: | College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030 |
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| Abstract: | 【OBJECTIVE】 To study the accumulation of cadmium and the changes of morphology in chicken liver induced by subchronic cadmium. 【METHOD】 30 normal Hyline white laying hens, aged 50 days, were randomly allocated to 3 groups and each group included 10 respectively. In feed, we added 0 mg/kg CdCl2, 140 mg/kg CdCl2, 210 mg/kg CdCl2 separately into control group, low-dosage cadmium group and high-dosage cadmium group. Liver was got to determinate the contents of cadmium and observe changes of microstructure or ultrastructure at 20d、40d and 60d after cadmium exposure. 【RESULTS】 Accumulation of cadmium in liver showed time-effect curve and dose-effect curve.Denaturation and necrosis of cadmium-group liver cell could be seen, mitochondria and endoplasmic reticulum were enormously damaged. 【CONCLUSION】 Liver was one of the target organ of cadmium and the damage of liver changed deeper with time goes on and elevation of cadmium dose. |
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| Keywords: | Chicken Cadmium toxication Liver Accumulation Ultrastructure |
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