| 多毛类动物对多环芳烃的毒性响应及代谢研究进展 |
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| 引用本文： | 蔡富才,李艳楠,赵欢,杨大佐,陈雪,周一兵.多毛类动物对多环芳烃的毒性响应及代谢研究进展[J].大连海洋大学学报,2017,32(1). |
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| 作者姓名： | 蔡富才 李艳楠 赵欢 杨大佐 陈雪 周一兵 |
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| 作者单位： | 大连海洋大学 辽宁省海洋生物资源恢复与生境修复重点实验室,辽宁 大连,116023 |
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| 基金项目： | 蓬莱19-3油田溢油事故海洋生态修复技术研究项目，国家自然科学基金资助项目，国家海洋公益性行业科研专项 |
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| 摘 要： | 多环芳烃可富集在水生生物体内,进而通过食物链的放大作用危害人类,多毛类动物是已知能够蓄积大量多环芳烃的物种,有关多毛类动物解毒代谢酶与抗氧化酶的活性及其基因表达水平作为多环芳烃监测指标的研究已有大量报道,但有关多毛类动物如何代谢蓄积在体内多环芳烃的基础理论研究目前尚处于初步阶段。本研究中,综述了近年来国内外有关多毛类动物对多环芳烃的毒性响应及代谢研究,多毛类动物对多环芳烃的代谢类似于脊椎动物,分为两个阶段,参与第一阶段代谢的酶主要是细胞色素P450酶家族,而尿苷二磷酸葡萄糖醛酸转移酶和磺基转移酶被认为是第二阶段代谢过程中起主导作用的酶类,针对目前研究中存在的问题,提出今后应加强多毛类动物对复合多环芳烃以及低剂量多环芳烃长期暴露的毒性响应研究,同时增强对不同多环芳烃的代谢研究。
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| 关 键 词： | 多毛类动物 多环芳烃 毒性响应 代谢 |
Toxicity and metabolism of polycyclic aromatic hydrocarbons in polychaetes: a review |
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| Authors: | CAI Fu-cai LI Yan-nan ZHAO Huan YANG Da-zuo CHEN Xue ZHOU Yi-bing |
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| Abstract: | Polycyclic aromatic hydrocarbons( PAHs) endanger the health of human beings through the food chain due to accumulation in aquatic organisms. Some polychaetes have been known to accumulate and metabolise certain PAHs. The activity and gene expression level of metabolic enzymes and antioxidant enzymes in polychaetes have been reported as a good indication in PAHs monitoring in water. However, the metabolic mechanism in polychaetes is still unclear. The toxicity and metabolism of PAHs in polychaetes are summarized in the current paper, and the metabolism of PAHs in marine polychaetes was found to be similar to that in vertebrates, which includes two pha-ses. In phase I, cytochrome P450 enzymes play an important role and uridine diphosphoglucuronyl transferase and sulfotransferase enzymes are considered to be the main enzymes in phase Ⅱ in polychaetes. Since there are some problems in the current research, the toxic effect of compound PAHs and low doses of PAHs in long exposure in polychaetes should be further investigated, especially the metabolism of different PAHs in polychaetes. |
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| Keywords: | polychaete polycyclic aromatic hydrocarbon toxic effect metabolism |
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