| 抗微生物药物PK-PD研究在优化兽药给药方案中的应用 |
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| 引用本文： | 高延玲,陈杖榴,王付民.抗微生物药物PK-PD研究在优化兽药给药方案中的应用[J].中国兽药杂志,2005,39(8):27-31. |
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| 作者姓名： | 高延玲 陈杖榴 王付民 |
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| 作者单位： | 华南农业大学广东省兽药研制与安全评价重点实验室,广东广州,510642 |
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| 摘 要： | PK-PD模型可用于优化兽药给药方案,制订合理的给药间隔和剂量,在减少细菌耐药性方面有重要意义.本文综述了β-内酰胺类、氨基糖苷类、氟喹诺酮类、大环内酯类等抗微生物药物的PK-PD研究现状,以期为兽药厂家在药物开发、设计合理的剂型与给药方案方面提供依据.
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| 关 键 词： | 药代动力学 药效动力学 优化给药方案 减少细菌耐药性 |
| 文章编号： | 1002-1280（2005）08-0027-05 |
| 收稿时间： | 2005-05-27 |
| 修稿时间： | 2005年5月27日 |
Pharmacokinetic-pharmacodynamic relationships of antimicrobial drugs in acquirring optimal regimen of veterinary medicine |
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| GAO Yan-ling,CHEN Zhang-liu,WANG Fu-min.Pharmacokinetic-pharmacodynamic relationships of antimicrobial drugs in acquirring optimal regimen of veterinary medicine[J].Chinese Journal of Veterinary Drug,2005,39(8):27-31. |
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| Authors: | GAO Yan-ling CHEN Zhang-liu WANG Fu-min |
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| Abstract: | The studies of pharmacokinetic-pharmacodynamics integration have important value on the design of antimicrobial regimen, thus directing rational adminstration and avoiding drug resistance. This review is mainly about PK-PD researches on beta lactams, aminoglycosides, fluoroquinolones, macrolides, etc. Hopefully it will be helpful for veterinary companies in developing new drugs and acquiring optimal regimen. |
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| Keywords: | pharmacokinetics pharmacodynamics optimal regimen drug resistance |
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