| 慢性阻塞性肺疾病的气道反应性与血清IL—8因子水平的研究 |
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| 引用本文： | 项阳,韩清韶.慢性阻塞性肺疾病的气道反应性与血清IL—8因子水平的研究[J].湛江医学院学报,1997,15(4):336-338. |
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| 作者姓名： | 项阳 韩清韶 |
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| 作者单位： | [1]南京医科大学 [2]广东医学院附属医院呼吸内科 |
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| 摘 要： | 目的：探讨慢性阻塞性肺疾病（ＣＯＰＤ）的气道反应性ＩＬ－８因子在ＣＯＰＤ发病中的作用，方法：用组胺气道吸入激发试验观察缓解期ＣＯＰＤ，哮喘和健康人的气道反应性，同时测定气道激发前后血清ＩＬ－８水平变化。结果：ＣＯＰＤ和哮喘患者均呈气道高反应性，且ＣＯＰＤ组ＰＤ５０ＦＥＶ１与ＦＥＶ１／Ｐｒｅ％（Ｐ〈０．０２，Ｐ〈０．０５），ＩＬ－８水平与ＰＤ２０ＦＥＶ１无显著相关性，气道激发后，ＣＯＰＤ和哮喘血清Ｉ
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| 关 键 词： | 肺疾病 阻塞性肺疾病 气道反应性 白细胞介素8 |
STUDY ON NATURE OF BRONCHIAL HYPERRESPONSIVENESS AND IL-8 SERUM LEVEL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
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| Xiang Yang,Han Qingshao.STUDY ON NATURE OF BRONCHIAL HYPERRESPONSIVENESS AND IL-8 SERUM LEVEL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE[J].Journal of Guangdong Medical College,1997,15(4):336-338. |
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| Authors: | Xiang Yang Han Qingshao |
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| Abstract: | Objective:To investigate the nature of bronchial responsiveness in patients with COPD and the effect of IL-8 on the pathogenesis of COPD. Methods:The airway rpactivity in subjects with COPD is studied by a bistamine inhalation test(HIT) compared with asthmatic patients and normal individuals.and the IL-8 serum concentration was determined by ELISA be fore and after HIT. Results :Both COPD and asthmatic patinets demonstrated bronchial hyperresponsiveness(BHR),and there was a positive cor-relation between the values of PD50FEV1 and FEV1/Pre % in COPD patients (r= 0. 418,P<0. 01). Sig-nificantly increased IL-8 level was found in the patients with stable COPD and asthma compared with that of the controls (P< 0.02, P< 0. 05, respectively), but there was no correlation between the in-creased IL-8 concertration and PD20FEV1 after HIT the IL-8 content in. patients with COPD and asthma decreased but not signifaicantly with CQPD (P>0. 05);and significantly with asthma(P<0. 02). Con-clusion: BHR seems to be a characteristic of COPD and IL-8 may play an important role in the pathogen-esis of COPD and asthma,and it rnay also be an anti-inflammatory cytokine in stable COPD and asthma. |
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| Keywords: | obstructive pulmonary disease bronchial responsiveness IL-8 |
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