| Abstract: | The fungitoxicity of iprodione to a sensitive strain of Botrytis cinerea was antagonised by a variety of cytochrome P-450 mixed function oxidase inhibitors. Piperonyl butoxide, metyrapone and N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide (MGK-264) at non-fungitoxic concentrations were strongly antagonistic, whereas sesamex, nuarimol, fenarimol, etaconazole and 6-nitro or 6-methoxy 1,2,3-benzothiadiazole were moderately antagonistic. Phenobarbital and 2-diethylaminoethyl 2,2-diphenylvalerate (SKF 525-A) were slightly antagonistic. The results suggest that fungitoxicity of iprodione may be dependent on an activation catalysed by a cytochrome P-450 mixed function oxidase. |
