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Pharmacokinetics of cephalexin in cats after oral administration of the antibiotic in tablet and paste preparations |
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| Authors: | JR THORNTON PJ MARTIN |
| Institution: | Division of Companion Animal Clinical Sciences, School of Veterinary Science, The University of Queensland, Queensland 4072;Virbac (Australia), 15 Pritchard Place, Peakhurst, New South Wales 2210 |
| Abstract: | Objective To determine the bioequivalence of a paste formulation of cephalexin with that of the tablet form. Design A two-way cross-over study. Animals Ten adult cats of mixed breed. Procedure The cats, randomly allocated to two groups, received either the paste preparation or the tablet orally at 12-hour intervals for 48 h before a 12-hour blood collection period. Two weeks later the treatments were reversed and the blood sampling repeated. The serum concentrations of the antibiotic were determined. The pharmacokinetic factors were analysed using a computer. Results There were no significant differences between the peak concentration of cephalexin, or the other pharmacokinetic factors obtained from the tablet and paste formulations. The serum profiles of cephalexin following four 12-hourly doses of each formulation were similar with the peak serum values occurring at approximately 2 h after administration. Conclusion The paste formulation and the tablet form are bioequivalent. |
| Keywords: | Pharmacokinetics cephalexin tablets paste cat |