Hypoglycemic effect of Mucuna pruriens seed extract on normal and streptozotocin-diabetic rats |
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| Authors: | Bhaskar Anusha Vidhya V G Ramya M |
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| Institution: | Department of Biotechnology, Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu 620 017, India. anushaparthiban@gmail.com |
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| Abstract: | The hypoglycemic effect of the aqueous extract of the seeds of Mucuna pruriens was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the seeds of Mucuna pririens (100 and 200 mg/kg body weight) significantly (P<0.001) reduced the blood glucose levels after an oral glucose load from 127.5+/-3.2 to 75.6+/-4.8 mg% 2 h after oral administration of seed extract. It also significantly lowered the blood glucose in STZ diabetic rats from 240.5+/-7.2 to 90.6+/-5.6 mg% after 21 days of daily oral administration of the extract (P<0.001). Thus, this study shows that M. pruriens has an anti-hyperglycemic action and it could be a source of hypoglycemic compounds. |
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