| 弓形虫卵囊感染小鼠的急性期与慢性期的脑组织蛋白质组变化 |
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| 引用本文： | 付明,贺君君,朱兴全,丛伟.弓形虫卵囊感染小鼠的急性期与慢性期的脑组织蛋白质组变化[J].畜牧兽医学报,2022,53(2):556-566. |
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| 作者姓名： | 付明 贺君君 朱兴全 丛伟 |
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| 作者单位： | 1. 山东大学海洋学院, 威海 264209;2. 中国农业科学院兰州兽医研究所/家畜疫病病原生物学国家重点实验室, 兰州 730046;3. 山西农业大学动物医学学院, 太谷 030801;4. 云南农业大学动物医学院, 云南省高校兽医公共卫生重点实验室, 昆明 650201 |
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| 基金项目： | 山东大学(威海)青年学者未来计划项目(20820211009);山东省博士后创新项目(202001005);山东省重点研发计划(公益类项目)(2019GSF108135);山西省“1331工程”项目(20211331-13);云南省专家工作站项目(202005AF150041)。 |
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| 摘 要： | 弓形虫是一种呈世界性分布的机会性致病原虫,可引起致命性脑炎.人弓形虫病急性感染往往与弓形虫卵囊污染密切相关.探究弓形虫卵囊感染对宿主的致病机制和防控弓形虫病具有重要意义.因此,本研究利用iTRAQ技术,结合2D-LC-MS/MS分析弓形虫PRU虫株卵囊急、慢性感染小鼠后,其脑组织蛋白质的差异表达情况.结果 表明,在急性...
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| 关 键 词： | 弓形虫 iTRAQ 脑组织 蛋白质组学 生物信息学分析 |
| 收稿时间： | 2021-05-07 |
Proteomic Analysis of Changes in the Mouse Brain Tissue Infected with Toxoplasma gondii Oocysts during the Acute and Chronic Stage |
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| FU Ming,HE Junjun,ZHU Xingquan,CONG Wei.Proteomic Analysis of Changes in the Mouse Brain Tissue Infected with Toxoplasma gondii Oocysts during the Acute and Chronic Stage[J].Acta Veterinaria et Zootechnica Sinica,2022,53(2):556-566. |
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| Authors: | FU Ming HE Junjun ZHU Xingquan CONG Wei |
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| Institution: | 1. Marine College, Shandong University, Weihai 264209, China;2. State Key Laboratory of Veterinary Etiological Biology/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China;3. College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China;4. Key Laboratory of Veterinary Public Health of Yunnan Province, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China |
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| Abstract: | Toxoplasma gondii is an opportunistic pathogen with a worldwide distribution,which can cause fatal encephalitis.Human acute toxoplasmosis is closely related to the contamination of T.gondii oocysts.To explore the pathogenic mechanism of T.gondii oocyst infection on the host and to prevent and control toxoplasmosis,we used iTRAQ to analyze the differential expression of proteins in mouse brain tissue after acute and chronic infection with T.gondii PRU strain oocysts.Compared with the control group,85 and 51 differentially expressed proteins were identified in the acute and chronic infection,respectively,while 114 proteins were differentially expressed in the chronic versus acute infection.The functional analysis revealed that these differentially expressed proteins are mainly involved in pathways such as immune and metabolic processes.The results of our study provide important data for elucidating the host brain tissue damage and pathogenic mechanism caused by T.gondii oocysts in the acute and chronic infection. |
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| Keywords: | Toxoplasma gondii iTRAQ brain proteomics bioinformatic analysis |
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