Production and characterization of monoclonal antibodies against formalin-inactivated Nipah virus isolated from the lungs of a pig |
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| Authors: | Imada Tadao Abdul Rahman Mohd Ali Kashiwazaki Yoshihito Tanimura Nobuhiko Syed Hassan Sharifah Jamaluddin Aziz |
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| Institution: | National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan. |
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| Abstract: | Eight clones of monoclonal antibodies (Mabs) to Nipah virus (NV) were produced against formalin-inactivated NV antigens. They reacted positive by indirect immunofluorescent antibody test, and one of them also demonstrated virus neutralizing activity. They were classified into six different types based on their biological properties. These Mabs will be useful for immunodiagnosis of NV infections in animals and further research studies involving the genomes and proteins of NV. |
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