|
|||||
|
|
Thyroid Dysplasia in Wistar Hannover GALAS Rats |
|
| Authors: | Weber Klaus Ernst Rainer Fankhauser Heinz Hardisty Jerry F Heider Wolfram Stevens Karla |
| Institution: | 1.Harlan Laboratories Ltd., Zelgliweg 1, 4452 Itingen, Switzerland;2.Schering AG Berlin, Berlin 13342, Germany;3.RCC Ltd., Zelgliweg 1, 4452 Itingen, Switzerland;4.EPL Inc., Research Triangle Park, North Carolina 27709, USA;5.Schering AG Berlin, Berlin 13342, Germany.;6.Harlan Laboratories, Inc., Indianapolis, IN 46250 USA |
| Abstract: | Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid. Heterozygous animals exhibited thyroid dysplasia with normal thyroid hormonal homeostasis and no difference in the incidence of preneoplastic or neoplastic lesions in oncogenicity studies. |
| Keywords: | thyroid gland dysplasia pituitary dwarfism GALAS rats |
| 本文献已被 PubMed 等数据库收录！ | |