| 疫苗佐剂胞嘧啶-鸟嘌呤寡脱氧核苷酸的研究进展 |
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| 引用本文： | 王亚丽,王振华,曾宪垠.疫苗佐剂胞嘧啶-鸟嘌呤寡脱氧核苷酸的研究进展[J].中国畜牧兽医,2011,38(6):49-52. |
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| 作者姓名： | 王亚丽 王振华 曾宪垠 |
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| 作者单位： | 1. 四川农业大学,四川雅安 625014;2. 成都农业科技职业学院畜牧兽医分院,四川温江 611130 |
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| 摘 要： | 胞嘧啶-鸟嘌呤寡脱氧核苷酸(cytosine phosphate guanidine oligodeoxynucleotide,CpG ODN)是指含有非甲基化的胞嘧啶和鸟嘌呤二核苷酸为核心序列的核苷酸序列,近年来,CpG ODN作为一种新型免疫佐剂的研究越来越多,可诱发机体产生多种免疫学效应,提高系统免疫和黏膜免疫水平,具有安全性高,耐受性强等特点。
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| 关 键 词： | CpG ODN 佐剂 系统免疫 黏膜免疫 |
| 收稿时间： | 2010-12-08 |
Progress on Vaccine Adjuvant CpG ODN |
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| WANG Ya-li,WANG Zhen-hua,ZENG Xian-yin.Progress on Vaccine Adjuvant CpG ODN[J].China Animal Husbandry & Veterinary Medicine,2011,38(6):49-52. |
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| Authors: | WANG Ya-li WANG Zhen-hua ZENG Xian-yin |
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| Institution: | 1. Sichuan Agricultural University,Ya’an 625014,China;2. Chengdu Vocational College of Agricultural Science and Technology, the Branch College of Animal and Veterinary, Wenjiang 611130,China |
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| Abstract: | Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate a variety of immunological effects. CpG ODN is used as vaccine adjuvants, where they increase the vaccine-specific immune responses and the mucosal immune responses. Ongoing clinical studies indicate that CpG ODN are safe and well-tolerated when administered as adjuvants to animals. |
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| Keywords: | CpG oligodeoxynucleotides adjuvant system immunity mucosal immunity |
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