| 紫海胆肠道真菌Aspergillus sp.HDf2次生代谢产物抗生物污损活性的研究 |
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| 引用本文： | 王,蓉,何,华,詹夏菲等.紫海胆肠道真菌Aspergillus sp.HDf2次生代谢产物抗生物污损活性的研究[J].安徽农业科学,2014(25):8492-8493. |
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| 作者姓名： | 王 蓉 何 华 詹夏菲等 |
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| 作者单位： | [1]海南省海洋与渔业科学院,海南海口570203; [2]中国热带农业科学院热带生物技术研究所农业部热带作物生物学与遗传资源利用重点实验室,海南海口571101 |
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| 基金项目： | 海南省自然科学基金项目（314176,313079）. |
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| 摘 要： | 目的]对紫海胆肠道曲霉菌Aspergillus sp.HDf2的次生代谢产物进行抗海洋生物污损活性研究。方法]采用摇瓶液体发酵,运用柱层析等方法,从发酵液中分离、纯化获得4个γ-丁烯酸内酯类单体化合物(-)-spiculisporic acid、spiculisporic acids B–D和1个secospiculisporic acid B,并且对其进行了抗藤壶幼虫附着活性测试。结果]化合物spiculisporic acid B和secospiculisporic acid B在浓度为25 mg/L时均具有抗藤壶幼虫附着活性,其中化合物secospiculisporic acid B活性最强,其他化合物无活性。结论]该研究首次报道它具有抗生物污损活性。
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| 关 键 词： | 曲霉菌 海洋真菌 次生代谢产物 抗污损 藤壶 |
Antifouling Secondary Metabolites from Sea Urchin-Associated Fungus Aspergillus sp.HDf2 |
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| Institution: | WANG Rong,HE Hua,ZHAN Xia-fei,HE Xiao-na,ZHOU Wen-jia,GUO Zhi-kai(1.Hainan Academy of Ocean and Fisheries Sciences, Haikou, Hainan 570203;2.Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101) |
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| Abstract: | Objective] Antifouling activity of the secondary metabolites from the sea urchin （Anthocidaris crassispina） associated fungus Aspergillus sp.HDf2 was investigated.Method] Four γ-butenolide derivatives,including （-）-spiculisporic acid,spiculisporic acids B-D,and one secospiculisporic acid 1B,were isolated from the filtrate of the fermented culture broth by chromatographic methods.Their anti-larval settlement activity against barnacle Balanus amphitrite were tested.Result] Only two compounds,spiculisporic acid B and secospiculisporic acid B,were active against the larval settlement of Balanus amphitrite under 25 mg/L,in which secospiculisporic acid B showed the strongest activity.Conclusion] The antifouling acitivity of these compounds were reported here for the first time. |
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| Keywords: | Aspergillus sp Marine fungus Secondary metabolites Antifouling Balanus amphitrite |
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