CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors |
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| Authors: | Madakamutil Loui T Christen Urs Lena Christopher J Wang-Zhu Yiran Attinger Antoine Sundarrajan Monisha Ellmeier Wilfried von Herrath Matthias G Jensen Peter Littman Dan R Cheroutre Hilde |
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| Institution: | La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. |
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| Abstract: | Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta+ T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha. |
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