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| 肉鸡热应激病理损伤与应激蛋白(HSP_(70))相关性研究 | |
| 引用本文： | 鲍恩东,龚远英,J.Hartung,付旭彬,王小军,张海涛,王志亮.肉鸡热应激病理损伤与应激蛋白(HSP_(70))相关性研究[J].中国农业科学,2004,37(2):301-301. |
| 作者姓名： | 鲍恩东 龚远英 J.Hartung 付旭彬 王小军 张海涛 王志亮 |
| 作者单位： | 1. 南京农业大学动物医学院,南京,210095 2. 汉诺威兽医学院动物卫生和动物福利研究所,汉诺威,德国 3. 农业部青岛动物检疫所,青岛,266032 |
| 基金项目： | 国家自然科学基金资助项目(39770569，30170682)，教育部留学人员回国基金资助项目，中德农业科技合作资助项目 |
| 摘 要： | 通过血液临床病理学、组织学和免疫组织化学检测技术,对AA肉鸡进行了为期10 h的急性热应激,观察分析了高热应激状态下受试鸡组织损伤及其与HSP70的相关性。热应激受试鸡组织脏器在应激初期即开始出现较明显的组织病理学改变,表现为心肌纤维、肾小管上皮细胞等呈现不同程度的变性、坏死等退行性变化;外周血液中反映受试鸡心肌等细胞组织损伤的肌酸激酶(对照)活性显著升高;反映鸡体基础代谢水平的甲状腺素T3和T4、胰岛素则呈现不同程度的下降趋势。应激持续较长时间(10 h)后受试鸡外周血液中对照含量下降的幅度明显趋缓的现象 |
| 关 键 词： | 肉鸡 应激蛋白 病理损伤 免疫组织化学 热应激 |
Relation Between Pathologic Damages and HSP70 Changes in Acute Heat Stressed Broilers |
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| BAO En-dong,GONG Yuan-ying,J Hartung,FU Xu-bin,WANG Xiao-jun ZHANG Hai-tao,WANG Zhi-liang.Relation Between Pathologic Damages and HSP70 Changes in Acute Heat Stressed Broilers[J].Scientia Agricultura Sinica,2004,37(2):301-301. | |
| Authors: | BAO En-dong GONG Yuan-ying J Hartung FU Xu-bin WANG Xiao-jun ZHANG Hai-tao WANG Zhi-liang |
| Institution: | BAO En-dong1,GONG Yuan-ying1,J Hartung2,FU Xu-bin1,WANG Xiao-jun1 ZHANG Hai-tao1,WANG Zhi-liang3 |
| Abstract: | The relation between tissue damages and intracellular HSP70 distribution of heat stressed broilers wasstudied after 10 h heat stress using clinical pathological, histological and immunohistochemistry technique. Obvioushistopathological lesions, such as degeneration and necrosis of myocardium and renal tubular epithalium, significantinduction of creatine kinase (CK) which refer to myocardium and hepatocytes damages in blood of heat stressed broilers,reduction tendency of thyroxin T3, T4 and insulin, were observed at the beginning of heat stress. It is postulated that thereduction tendency of CK activity is involved in the induction of HSP70 in the myocardium of heat stressed broilers undercontinuing heat stress. It is reasonable to hypothesize that the localization of prominent HSP70 in blood vessel is related tothe vessel function. |
| Keywords: | Broiler Heat shock protein70 Histopathology Immunohistochemistry Heat stress |
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