| 不同工艺制备替米考星固体分散体及溶出特性研究 |
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| 引用本文： | 吕彪,刘三侠,宋志元,储君,刘建,孙雪峰,张要齐.不同工艺制备替米考星固体分散体及溶出特性研究[J].中国动物保健,2014(12):11-15. |
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| 作者姓名： | 吕彪 刘三侠 宋志元 储君 刘建 孙雪峰 张要齐 |
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| 作者单位： | 新密市动物卫生监督所;河南惠通天下生物工程有限公司 |
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| 基金项目： | 新郑市科技攻关项目（2（113PTG10）. |
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| 摘 要： | 不同工艺制备替米考星固体分散体并研究其溶出特性。通过单因素考察选择载体与药载比后,采用正交设计优选替米考星固体分散体制备工艺,以药物溶出率为考察指标,搅拌速度、搅拌时间、固化时间作为影响因素,每个因素取3个水平,并利用HPLC法测定替米考星含量。结果表明,采用熔融法,以Poloxamer l88为载体,药载比为1∶3,中速搅拌45 min,固化12 h,优化得到的工艺稳定可行,溶出效果较好。
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| 关 键 词： | 替米考星 固体分散体 HPLC 溶出度 |
Different Preparation of Tilmieosin Solid Dispersion and Dissolution Characteristics Research |
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| Institution: | Lv Biao, Liu Sanxia, Song Zhiyuan, Chu Jun, Liu Jian, Sun Xuefeng, Zhang Yaoqi (Xinmi Animal Health Supervision Institute, Xinmi Henan, 452370; Henan HuiTongTianXia biologieal engineering co., LTD, Xinzheng Henan, 451162) |
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| Abstract: | Different preparation of Tilmicosin solid dispersion and study ils dissolution characterislics. By usingsingle factor test choose carrier and drug carrier ratio, optimized by orthogonal design of tihnicosin solid dispersion preparation process, taking the drug dissolution rate as the study index, stirring speed, stirring lime, curing time as influencing factors, each factor takes three levels, and determination of Tilmicosin content by HPLC method. The results show that. by melting method, with Poloxamer 188 as the carrier, drug carrier ratio is 1：3, medium speed for 45 rain, curing for 12 h, the optimized process is stable and feasible, has better dissolution effect. |
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| Keywords: | Tilmicosin Solid Dispersion HPLC Dissolution |
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