| 骨形态发生蛋白4与哺乳动物卵泡发育的研究进展 |
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| 引用本文： | 张驰,周建设,秦楠,李明,陈其新.骨形态发生蛋白4与哺乳动物卵泡发育的研究进展[J].中国畜牧兽医,2010,37(3):141-144. |
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| 作者姓名： | 张驰 周建设 秦楠 李明 陈其新 |
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| 作者单位： | （河南农业大学牧医工程学院， 郑州 450002） |
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| 基金项目： | 河南省重点科技攻关项目(0524030011) |
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| 摘 要： | 骨形态发生蛋白4(bone morphogenetic protein-4,BMP-4)属于转化生长因子超家族成员(TGF-β),参与机体的细胞生长、分化、凋亡、迁移及细胞外基质形成等众多病理、生理活动的调控。BMP-4基因与哺乳动物的繁殖性能密切相关,尤其在卵泡的生长分化过程中起着重要的调控作用,是原始卵泡和卵母细胞生存的必需因子。作者就骨形态发生蛋白4的基因结构、受体种类、信号调控机制及该基因与哺乳动物卵泡发育的关系作一综述。
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| 关 键 词： | 骨形态发生蛋白4 信号调控机制 卵泡发育 |
Progress on Bone Morphogenetic Protein 4 on Mammalian Follicular Development |
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| ZHANG Chi,ZHOU Jian-she,QIN Nan,LI Ming,CHEN Qi-xin.Progress on Bone Morphogenetic Protein 4 on Mammalian Follicular Development[J].China Animal Husbandry & Veterinary Medicine,2010,37(3):141-144. |
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| Authors: | ZHANG Chi ZHOU Jian-she QIN Nan LI Ming CHEN Qi-xin |
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| Institution: | (College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhenzhou 450002,China) |
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| Abstract: | Bone morphogenetic proteins 4(BMP-4) is belonging to the transfer growth factor(TGF-β) superfamily.It involves in the cell of body growth,polarization,apoptosis,migration and the formation of extracellular matrix and many other pathological and physiological activity. Recent studies have shown that BMP-4 gene is closely related to the reproductive performance of mammals.It is a crucial factor in follicular growth and development in the mammalian ovary.In this review，the structure，function and regulation of BMP-4 were introduced．The relationships between BMP-4 gene and follicular development were also discussed in mammals. |
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| Keywords: | bone morphogenetic protein 4 signal transduction follicular development |
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