| 环核苷酸（cAMP／cGMP）与肉鸡内分泌及免疫功能的关系 |
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| 引用本文： | 阮晖,牛冬,石放雄,洪奇华.环核苷酸（cAMP／cGMP）与肉鸡内分泌及免疫功能的关系[J].中国兽医学报,2001,21(3):278-280. |
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| 作者姓名： | 阮晖 牛冬 石放雄 洪奇华 |
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| 作者单位： | 浙江大学动物科学学院, |
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| 摘 要： | 以艾维茵肉鸡为实验对象，研究了血清环核苷酸与肉鸡内分汔及免疫功能的关系。结果表明，以性法氏囊病病毒（IBDV）强毒株攻击后，肉鸡垂体－肾上腺轴活动加强，并发生针对IBDV的特异性免疫反应，血清cAMP与cGMP含量均上升，但cAMP/cGMP比值保持稳定，提示垂体－肾上腺轴活动加强使cAMP上升与抗IBDV特异性免疫细胞内效应大分子的合成有关，而cAMP/cGMP比值的稳定则是保持一种高阈平衡，以维持内环境的稳态。由于IBDV强毒株破坏了机体免疫系统，未经IBDV疫苗免疫的肉鸡cAMP、抗IBDV抗体和IL－2的上升幅度均比经IBDV疫苗免疫的肉鸡小。
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| 关 键 词： | 肉鸡 传染性法氏囊病病毒 环腺苷酸 环鸟苷酸 垂体－肾上腺轴 免疫功能 调节作用 |
| 文章编号： | 1005-4545(2001)03-0278-03 |
| 修稿时间： | 2000年7月15日 |
Study on the Relationship between Cyclic Nucleotides and Endocrine and Immunity |
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| RUAN Hui,NIU Dong,SHI Fang xiong,HONG Qi hua.Study on the Relationship between Cyclic Nucleotides and Endocrine and Immunity[J].Chinese Journal of Veterinary Science,2001,21(3):278-280. |
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| Authors: | RUAN Hui NIU Dong SHI Fang xiong HONG Qi hua |
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| Abstract: | Avain broilers were used as experimental objects to study the relationship between the serum cyclic neucleotide and endocrine and immunity.The results showed that after infection with virulent infectious bursal disease virus(IBDV),the pituitary adrenal axis and immune system were activated,serum cAMP and cGMP increased while cAMP/cGMP remained unchanged indicating that the activation of pituitary adrenal axis and increase of cAMP concentration results in the production of specific molecules in specific immune cells and the unchanged cAMP/cGMP would maintain the homeostasis.The serum cAMP,IL 2 and antibody against IBDV in the broilers not immunized with IBDV vaccine were less than in immunized broilers suggesting that IBDV infection may hurt the immune system. |
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| Keywords: | broiler infectious bursal disease virus cAMP cGMP pituitary adrenal axis immunity function |
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