| 4-羟基-3-甲氧基苯乙腈的合成方法改进研究 |
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| 引用本文： | 赖宜天.4-羟基-3-甲氧基苯乙腈的合成方法改进研究[J].安徽农业科学,2012,40(26):12882-12883,12885. |
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| 作者姓名： | 赖宜天 |
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| 作者单位： | 青海大学化工学院,青海西宁,810016 |
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| 摘 要： | 目的]改进4-羟基-3-甲氧基苯乙腈的合成工艺。方法]以香兰素为原料,采用KF/Al2O3为脱水剂,经过多步反应合成了4-羟基-3-甲氧基苯乙腈。结果]反应的优化条件为:3-甲氧基-4-乙酰氧基苯乙醛和盐酸羟胺的摩尔比为1.0∶1.2;反应温度为100℃;反应时间为7.5 h;KF和Al2O3的质量比为1.0∶1.5。用元素分析,红外光谱和1H NMR确定了目标化合物的结构。结论]该路线是一种简单、经济的方法。
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| 关 键 词： | 4-羟基-3-甲氧基苯乙腈 香兰素 合成 |
Improvement of the Synthesis Method of 4-hydroxy-3-methoxyphenylacetonitrile |
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| LAI Yi-tian.Improvement of the Synthesis Method of 4-hydroxy-3-methoxyphenylacetonitrile[J].Journal of Anhui Agricultural Sciences,2012,40(26):12882-12883,12885. |
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| Authors: | LAI Yi-tian |
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| Institution: | LAI Yi-tian(College of Chemical Engineering,Qinghai University,Xining,Qinghai 810016) |
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| Abstract: | Objective] To improve the synthesis process of 4-hydroxy-3-methoxy phenylacetonitrile.Method] By using KF/Al2O3 as dehydrant,the 4-hydroxy-3-methoxyphenylacetonitrile was synthesized from the raw material of vanillin via multiple steps.Result] Optimal reaction conditions were 1.0∶1.2 of 3-methoxy-4-acetoxyphenylacetonitrile:hydroxylamine hydrochloride(molar ratio),100 ℃ of temperature,7.5 h of time,and 1.0∶1.5 of KF∶Al2O3(quality ratio).The structure of these compounds has been determined by IR spectra,elemental analysis and 1H NMR.Conclusion] The reported method is simple and economical. |
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| Keywords: | 4-hydroxy-3-methoxyphenylacetonitrile Vanillin Synthesis |
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