| 双氢杨梅素在家兔体内的药动学研究 |
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| 引用本文： | 欧贤红,叶勇.双氢杨梅素在家兔体内的药动学研究[J].安徽农业科学,2012,40(16):8941-8942. |
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| 作者姓名： | 欧贤红 叶勇 |
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| 作者单位： | 桂林医学院,广西桂林,541004;广西医科大学,广西南宁530021;桂林莱茵生物科技股份有限公司博士后工作站,广西桂林541100 |
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| 基金项目： | 广西教育厅基金项目(201010LX340) |
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| 摘 要： | 目的]研究双氢杨梅素在家兔体内的药动学特征。方法]经单剂口服给药后,收集家兔血样,经离心后,采用紫外分光光度法于280 nm波长处进行血药浓度测定。结果]双氢杨梅素的血药浓度—时间曲线符合一级消除的单室模型,Ke为(0.76±0.13)h-1,Ka为(0.85±0.24)h-1,t1/2(Ka)为(0.82±0.31)h,t 1/2(Ke)为(0.91±0.44)h,Tmax为(1.5±0.46)h,Cmax为(12.36±2.7)mg/L,AUC0→∞为(45.45±22.3)mg.h/L,CL/F为(4.71±1.21)L/(h.kg),V/F为(6.17±3.12)L/kg。结论]该方法简便、可靠、灵敏,适用于双氢杨梅素的药动学研究。
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| 关 键 词： | 双氢杨梅素 药动学 紫外分光光度法 |
Study on the Pharmacokinetics of Dihydromyricetin in Rabbits |
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| Institution: | OU Xian-hong et al(Guilin Medical University,Guilin,Guangxi 541004) |
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| Abstract: | Objective] To study the pharmacokinetics of dihydromyricetin in rabbits.Method] After oral administration with dihydromyricetin at a single dose,the blood samples of rabbits were collected and centrifuged.Dihydromyricetin concentration was determined with UV spectrophotometry at the wavelength of 280 nm.Result] The concentration-time curve of dihydromyricetin was described by a single compartment model,Ke was(0.76±0.13)h-1,Ka was(0.85 ± 0.24)h-1,t1/2(Ka) was(0.82±0.31)h,t1/2(Ke) was(0.91 ± 0.44)h,Tmax was(1.5 ± 0.46)h,Cmax was(12.36±2.7)mg/L,AUC0→∞ was(45.45 ± 22.3)mg·h/L,CL/F was(4.71±1.21)L/(h·kg),V/F was(6.17±3.12)L/kg.Conclusion] The method is simple,reliable and sensitive and can be used for the pharmacokinetic research of dihydromyricetin. |
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| Keywords: | Dihydromyricetin Pharmacokinetics UV spectrophotometry |
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