The effects of acute exposure to deoxynivalenol on some inflammatory parameters in miniature pigs |
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| Authors: | Mikami Osamu Kubo Midori Murata Hideo Muneta Yoshihiro Nakajima Yasuyuki Miyazaki Shigeru Tanimura Nobuhiko Katsuda Ken |
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| Institution: | Safety Research Team, National Institute of Animal Health, Tsukuba, Ibaraki, Japan. mikami@affrc.go.jp |
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| Abstract: | Seven miniature pigs were injected intravenously with deoxynivalenol (DON) at 1 mg/kg body weight; afterward, the number of leukocytes in peripheral blood, the luminol-dependent chemiluminescence of neutrophils, the serum or plasma concentration of cytokines and acute-phase proteins were evaluated to determine the effects of acute exposure to DON on inflammatory responses. White blood cell counts were transiently increased at 3, 6, and 12 hr post-injection (PI) due to the increased number of neutrophils. The luminol-dependent chemiluminescence value of neutrophils was significantly elevated at 24 hr PI, indicating the activation of the bactericidal function of neutrophils. Significant increases of interleukin (IL)-8 and tumor necrosis factor-α at 3 hr PI and IL-6 at 6 hr PI were detected in the serum. The concentration of haptoglobin and serum amyloid A was significantly increased at 24 hr PI. These results suggest that acute exposure to DON induced a temporary recruitment of neutrophils in the peripheral blood by IL-8 and subsequent activation of the bactericidal function, and a transient increase of proinflammatory cytokines and acute-phase proteins, indicating the immunomodulatory effects of DON in pigs. |
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