Effects of sodium fluoride on hepatic toxicity in adult mice and their suckling pups |
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| Institution: | 1. Animal Physiology Laboratory, Sciences Life Department, Sciences Faculty of Sfax, Tunisia;2. Urology Service, CHU Habib Bourguiba-Sfax, Tunisia;3. Biochemistry Laboratory, CHU Habib Bourguiba-Sfax, Tunisia;4. Histopathology Laboratory, CHU Habib Bourguiba-Sfax, Tunisia;1. Department of Urology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;2. Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey;3. Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;4. Department of Medical Biochemistry, Instute of Health Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey;5. Department of Medical Services and Techniques, Vocational School of Health Services, Recep Tayyip Erdogan University, 53100 Rize, Turkey;6. Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey;1. Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, PR China;2. School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China;3. Tanggu Center for Disease Control and Prevention, 43 Fujiang Road, Tianjin Binhai New Area, Tianjin 300450, PR China;4. Department of Environmental Health and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030 Hubei, PR China;1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471003, China;2. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA |
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| Abstract: | In this investigation, we have evaluated the effect of sodium fluoride (NaF) on hepatic function in pregnant and lactating mice and their suckling pups. Experiments were carried out on female Wistar mice given 500 ppm sodium fluoride (226 ppm fluoride ion) in their drinking water from the 15th day of pregnancy until day 14 after delivery. All mice were sacrificed on day 14 after parturition. Our results showed a significant decrease in serum levels of total protein and albumin, a marked hypoglycaemia and a significant decline in serum cholesterol and triglyceride levels in fluoride-treated mice and their pups. Whereas globulin and biluribin levels in serum were not significantly changed by NaF treatment. On the other hand, serum transaminase activities (aspartate transaminase; alanine transaminase), which well known as markers of liver function, were elevated indicating hepatic cells’ damage after treatment with fluoride. Lipid peroxidation increased in NaF-treated mice and pups, as revealed by high liver malondialdehyde levels, while serum total antioxidant status showed a significant decline. These biochemical modifications in NaF-treated mice also correspond histologically with extensive ballooning, hepatocellular necrosis and infiltration of mononuclear cells. These effects were not observed in controls. |
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