| QuEChERS-UPLC-MS/MS快速测定鸡肝中七种磺胺类药物残留 |
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| 引用本文： | 耿士伟.QuEChERS-UPLC-MS/MS快速测定鸡肝中七种磺胺类药物残留[J].中国兽药杂志,2011,45(10):16-19. |
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| 作者姓名： | 耿士伟 |
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| 作者单位： | 1. 江苏省畜产品质量检验测试中心,南京,210036
2. 沃特世科技（中国）有限公司,上海,201203 |
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| 摘 要： | 建立了一种通过QuEChERS方法和超高效液相色谱-串联质谱法快速测定鸡肝中七种磺胺类药物残留量的方法。样品以磺胺二甲氧嘧啶-D6为内标,经DisQuE萃取管提取,DisQuE净化管净化,浓缩后经超高效液相色谱分离,串联质谱测定。结果表明在12.5～125 ng/mL范围内各磺胺类药物均呈良好的线性关系,高中低浓度回收率在70%～115%,精密度小于15%。该方法快速、简便,适于鸡肝中七种磺胺类药物的批量测定。
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| 关 键 词： | QuEChERS 超高效液相色谱-串联质谱 磺胺 鸡肝 残留 |
| 收稿时间： | 6/29/2011 9:55:33 AM |
| 修稿时间： | 7/11/2011 8:16:15 AM |
Rapid determination of seven sulphonamides in chicken liver by UPLC-MS/MS via QuEChERS |
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| gengshiwei.Rapid determination of seven sulphonamides in chicken liver by UPLC-MS/MS via QuEChERS[J].Chinese Journal of Veterinary Drug,2011,45(10):16-19. |
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| Authors: | gengshiwei |
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| Institution: | Jiangsu Quality Inspection and Testing Center for Animal Products |
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| Abstract: | An ultra performance liquid chromatography tandem mass spectrometric method was developed for rapid determination of seven sulphonamides residues in chicken liver via QuEChERS.Sulfadimethoxine-D6 was used as internal standard.The sample was extracted by DisQuE extraction tube,cleaned up by DisQuE clean-up tube.After concentration,it was analyzed by UPLC-MS/MS.The results showed that good linearity in the ranges of 12.5~125 ng/mL for each sulphonamide component.The recoveries were between 70% and 115%,and precision was lower 15%.The method was simple and rapid,and it was suitable to detect sulphonamides residuals with high throughput. |
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| Keywords: | QuEChERS UPLC-MS/MS sulphonamides chicken liver residuals |
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