Evaluation of the virulence of some strains of peste-des-petits-ruminants virus (PPRV) in experimentally infected West African dwarf goats |
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| Authors: | Couacy-Hymann E Bodjo C Danho T Libeau G Diallo A |
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| Institution: | 1. LANADA/Laboratoire Central de Pathologie Animale, BP 206, Bingerville, Côte d’Ivoire;2. CIRAD, Programme Santé Animale, TA 30/G, Campus International de Baillarguet, 34398 Montpellier, Cedex 5, France;3. Animal Production Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories, A-2444 Seibersdorf, Austria;1. Animal Production and Health Laboratory, FAO/IAEA Agriculture and & Biotechnology Laboratory, IAEA Laboratories Seibersdorf, International Atomic Energy Agency (IAEA), Wagramer Strasse 5, P.O. Box 100, A1400, Vienna, Austria;2. Pan African Veterinary Vaccine Center of the African Union (AU-PANVAC), P.O Box 1746, Debre-Zeit, Ethiopia;3. Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety, Moedling, Austria (AGES);1. Department of Veterinary Medicine, Infectious Diseases Division, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;2. Department of Virology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;3. Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, United States;1. Institut National de Médecine Vétérinaire (INMV), Cinq Maison, El Harrach, Algiers, Algeria;2. Laboratoire de Recherche “Santé et Productions Animales”, Ecole Nationale Supérieure Vétérinaire d''Alger, El Alia, Algiers, Algeria;3. Applied Biotechnology Division, National Veterinary Research Institute, PMB 1, Vom, Plateau State, Nigeria;1. CIRAD, UMR CMAEE, F-34398 Montpellier, France;2. INRA, UMR1309 CMAEE, F-34398 Montpellier, France;3. National Animal health Diagnosis and Investigation Center (NAHDIC), P.O. Box 04, Sebeta, Ethiopia;4. Animal Production and Health Laboratory, FAO/IAEA Agriculture & Biotechnology Laboratory, IAEA Laboratories, International Atomic Energy Agency, Wagramer Strasse 5, P.O. Box 100, A-1400 Vienna, Austria;5. CIRAD, UMR CMAEE, F-97170 Petit-Bourg, Guadeloupe, France;1. College of Agriculture and Environmental Sciences, Bahr Dar University, P.O. Box 79, Bahir Dar, Ethiopia;2. College of Veterinary Medicine and Animals Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia;3. The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK;4. National Animal Health Diagnostic and Investigation Center, P. O. Box 04, Sebeta, Ethiopia;5. Institute of Infection and Global Health, University of Liverpool, IC2 Building, 146 Brownlow Hill, Liverpool, L3 5RF, UK |
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| Abstract: | Different isolates of peste-des-petits-ruminants virus (PPRV) from outbreaks in Africa and India were investigated for virulence in West African dwarf goats in the Ivory Coast. Six groups of five animals received a virulent suspension of various strains of virus at a concentration of 103 TCID50/mL and the goats were observed for 15 days after infection. The Côte-d’Ivoire 89 (CI89), Guinea Conakry and Bissau Guinea PPRV strains caused a peracute disease; the India-Calcutta strain caused acute disease; the Sudan-Sennar strain produced an acute to mild disease, while the Nigeria 75/1 wild-type strain caused a mild disease and the animals recovered. The viruses studied contained examples of PPRV from specific lineage groups based on their nucleoprotein PPRV gene. This experiment indicated that virulence characteristics might be a useful marker to help classify PPRV isolates. |
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