| 克隆动物的端粒长度研究进展 |
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| 引用本文： | 吕昆,林丹,黄英.克隆动物的端粒长度研究进展[J].中国畜牧兽医,2009,36(11):99-104. |
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| 作者姓名： | 吕昆 林丹 黄英 |
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| 作者单位： | （上海交通大学医学院医学遗传研究所 卫生部医学胚胎分子生物学重点实验室 上海市生殖与胚胎工程重点实验室， 上海 200040） |
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| 基金项目： | 国家"863"重点项目"人药用蛋白动物乳腺生物反应器"，上海市科委产学研项目"应用体细胞克隆技术扩繁良种奶牛种群" |
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| 摘 要： | 端粒是真核染色体分子末端的DNA区域，是由重复的DNA序列和端粒结合蛋白形成的DNA-蛋白复合物，对于染色体的复制和稳定起着重要作用。近年来研究结果表明，端粒长度的缩短与人类疾病和衰老密切相关。同时，体细胞核移植(somatic cell nuclear transfer，SCNT)作为一种有效的无性生殖手段，越来越多的在科研和生产中得到应用。由于体细胞核移植通常采用体细胞作为核供体细胞，因而供体细胞的端粒长度、核移植后重组胚的端粒在胚胎早期是否会被修复、端粒长度是否有变化等问题，对于研究克隆动物的重编程、发育生物学都有着重要的指导意义。作者将对端粒的结构和端粒长度的机理研究、在克隆哺乳动物中对端粒长度的探索研究，以及近几年来关于端粒方面的一些研究进展加以阐述。
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| 关 键 词： | 端粒 端粒长度 哺乳动物 体细胞核移植 |
Research of Telomere Length in Cloned Animals |
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| LV Kun,LIN Dan,HUANG Ying.Research of Telomere Length in Cloned Animals[J].China Animal Husbandry & Veterinary Medicine,2009,36(11):99-104. |
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| Authors: | LV Kun LIN Dan HUANG Ying |
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| Institution: | (Shanghai Institution of Medical Genetics, Shanghai Jiao Tong University; Key Laboratory of Embryo Molecular Biology, Ministry of Health; Shanghai Laboratory of Embryo and Reproduction Engineering, Shanghai 200040, China) |
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| Abstract: | Telomeres are composed of repeated DNA sequences and specific DNA-binding proteins, which form a nucleoprotein complex at the end of eukaryotic chromosomes, and play an important role in the replication and stability of the telomeres. Recent researches indicate that telomere-shorten is closely related to disease and aging of the human. Being considered as an available instrument of agamogenesis, somatic cell nuclear transfer (SCNT) is widely applied in research and production. However, restricted by the fact that donor cells are always adult somatic cells, which contain shortened telomeres, it is significant to ensure whether telomeres of cloned animals are restored in the embryogenesis or not. In this article, authors review the latest researches about the structure of telomere, telomere maintain mechanism and telomere length of cloned mammals. |
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| Keywords: | telomere telomere length mammal somatic cell nuclear transfer |
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