| 硒和维生素E在硒缺乏动物自由基代谢中作用机制的研究 |
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| 引用本文： | 张世珍,王兴亚.硒和维生素E在硒缺乏动物自由基代谢中作用机制的研究[J].畜牧兽医学报,1997,28(4):311-317. |
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| 作者姓名： | 张世珍 王兴亚 |
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| 作者单位： | 中国农业科学院中兽医研究所 |
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| 摘 要： | 为阐明硒缺乏动物自由基代谢与硒缺乏症发病学的关系，以及硒和ＶＥ在自由基代谢中的作用采用低Ｓｅ日粮饲喂小鼠，并对血液、肝组织丙二醛、硒谷胱甘肽过氧化物酶、相关向量元素及自由基水平进行了系统检测。
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| 关 键 词： | 硒缺乏症 自由基代谢 硒 维生素E 动物 |
STUDIES ON THE MECHANISM AND THE EFFECTS OF SELENIUM AND VITAMIN E IN THE FREE RADICALS METABOLISM OF ANIMALS WITH SELENIUM DEFICIENCY |
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| Zhang Shizhen,WangXingya,Qi Zhiming,Li Shiping Li Jianxi,Meng Jiaren,Wang Yuwen,ZhuYuan.STUDIES ON THE MECHANISM AND THE EFFECTS OF SELENIUM AND VITAMIN E IN THE FREE RADICALS METABOLISM OF ANIMALS WITH SELENIUM DEFICIENCY[J].Acta Veterinaria et Zootechnica Sinica,1997,28(4):311-317. |
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| Authors: | Zhang Shizhen WangXingya Qi Zhiming Li Shiping Li Jianxi Meng Jiaren Wang Yuwen ZhuYuan |
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| Abstract: | To clarify the relationship between free radicals metabolism and the pathogenesis of selenium deficiency,and the effects of selenium(Se)and Vitamin E(V E) on free radicals metabolism,120 mice were fed with different diets,which containing less then 0.001 mg/kg Se(Se -),2.06mg/kg Se(Se - Se),100mg/kg V E (Se - V E),and 2.06mg/kg Se plus 100mg/kg V E(Se - Se V E),respectively.Molonaldehyde(MDA) concentration in serum and liver,Se Glutathione Peroxidase(Se GSH Px) activity of whole blood and liver,relevant mineral elements concentration and free radicals concentration in liver were investigated in different experimental groups.The disorder of free radicals metabolism was found in Se - group,which was characterized by the dramatical increase of MDA,FRs concentration in serum and liver,and marked decrease of Se GSH Px activity in whole blood and liver;The marked rise of Se GSH Px activity and decline of MDA,free radicals concentration in relevant tissues were found after Se supplementation,but only the decrease of MDA concentration was found after V E supplementation;Also the decrease of MDA concentration of serum and liver in Se - Se V E group was greater than that in Se - Se,Se - V E groups. The results showed that the free radical damage mechanism induced by the disorder of free radicals metabolism might play an important role in the pathogenesis of Se deficiency.The effects of Se on free radicals metabolism included the involvement in the action of scavenging peroxide as a necessary component of glutathione peroxidase,and the antioxidant property through the directly scavenging on free radicals.However,V E was mainly involved in the protection against the lipid peroxidation of biological membranes,acting as potent antioxidant.The results also suggested that Se and V E worked synergistically to protect lipid peroxidation by means of the inhibition/enzymolysis on the chain of peroxidation of unsaturated fatty acid. |
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| Keywords: | Selenium deficiency Free radical metabolism Selenium Vitamin E |
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