| 改进的QuEChERS-高效液相色谱-串联质谱法同时测定蔬菜水果中百菌清及其代谢物残留 |
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| 引用本文： | 毕瑞锋,邓锁成,付萌,张伟伟,张义霞.改进的QuEChERS-高效液相色谱-串联质谱法同时测定蔬菜水果中百菌清及其代谢物残留[J].农药学学报,2022,24(2):429-434. |
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| 作者姓名： | 毕瑞锋 邓锁成 付萌 张伟伟 张义霞 |
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| 作者单位： | 1.诺安实力可商品检验(青岛)有限公司，山东 青岛 266012 |
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| 摘 要： | 建立了同时检测蔬菜水果中百菌清及其代谢物4-羟基百菌清的高效液相色谱-串联质谱分析方法.样品经酸化乙腈提取后,采用配备大气压化学电离源的三重四极杆串联质谱仪测定.结果表明:百菌清及其代谢物4-羟基百菌清在0.005～0.2 mg/L范围内峰面积与质量浓度的线性关系良好,决定系数(R2)大于0.99;方法定量限为0.01...
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| 关 键 词： | QuEChERS 高效液相色谱-串联质谱 大气压化学电离源(APCI) 百菌清 4-羟基百菌清 蔬菜水果 |
| 收稿时间： | 2021-08-10 |
Simultaneous determination of chlorothalonil and its metabolite in fruits and vegetables using modified QuEChERS-high performance liquid chromatography-tandem mass spectrometry |
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| Institution: | 1.Sino Silliker Testing Services (Qingdao) Co., Ltd, Qingdao 266012, Shandong Province, China2.Mérieux NutriSciences (China) RD Department, Qingdao 266012, Shandong Province, China |
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| Abstract: | An analytical method for simultaneous determination of chlorothalonil and its metabolite chlorothalonil-4-hydroxy in fruits and vegetables was developed using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The samples were extracted by acidified acetonitrile, and the extraction solution was analyzed by HPLC-MS/MS equipped with APCI ion source. The results showed that good linearity was obtained in the range of 0.005-0.2 mg/L with correlation coefficients (R2) greater than 0.99. The limits of quantification were 0.01 mg/kg. At the spiked levels of 0.01, 0.05, and 0.2 mg/kg, the average recoveries in four sample matrices (cabbage, cucumber, grape, and apple) were 83%-104% with the relative standard deviations (RSDs) varying from 0.73% to 7.7% (n=6). The proposed method is simple, rapid, accurate and reliable, and it is suitable for the quantitative determination of chlorothalonil and its metabolite in fruits and vegetables. |
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