COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF <sup><nobr>99m</nobr></sup>Tc-DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF ^99mTc-DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS

Authors:	Paul Y Barthez DVM William J Hornof DVM MS Larry D Cowgill DVM PhD Larry A Neal BS Paul Mickel

Institution:	Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616.;Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616.;Department of Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616.

Abstract:	The scintigraphically measured percentage dose uptake of ^99mTc-DTPA by the kidneys and the plasma clearance of ^99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the ^99mTc-DTPA plasma clearance was better ( p =.0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of ^99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.

Keywords:	dog GFR ^99mTc-DTPA scintigraphy