G protein-coupled receptors in Anopheles gambiae |
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| Authors: | Hill Catherine A Fox A Nicole Pitts R Jason Kent Lauren B Tan Perciliz L Chrystal Mathew A Cravchik Anibal Collins Frank H Robertson Hugh M Zwiebel Laurence J |
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| Institution: | Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. |
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| Abstract: | We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation. |
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