Effects of oral ursodeoxycholic acid in healthy cats on clinicopathological parameters, serum bile acids and light microscopic and ultrastructural features of the liver |
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| Authors: | B T Nicholson S A Center J F Randolph P J Rowland M B Thompson A E Yeager H N Erb J CorbettD Watrous |
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| Institution: | Section of Small Animal Medicine, Cornell University, Ithaca, NY 14853, USA;Section of Pathology, Cornell University, Ithaca, NY 14853, USA;Department of Health and Human Services, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA;Section of Radiology, Cornell University, Ithaca, NY 14853, USA;Section of Epidemiology, Cornell University, Ithaca, NY 14853, USA;Section of Small Animal Medicine, Cornell University, Ithaca, NY 14853, USA |
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| Abstract: | A blind, placebo-controlled study evaluated the effects of ursodeoxycholic acid (UDCA) given orally, at a dose of 15 mg kg−1 per day for eight weeks, on the physical condition, haematological and serum biochemical profiles, urinalysis, total serum bile acids (
) and hepatic histology of four healthy cats. There were no clinically important significant differences between the groups or within the treatment groups in clinicopathological parameters,
concentrations or histology. A significant lower concentration/proportion of taurochenodeoxycholic acid was observed in the treated cats (P=0·05). Only one treated cat accumulated measurable quantities of
, and the compound appeared to be non-toxic. It did not, increase the concentration of
, and accumulated minimally in the serum. It should be investigated for therapeutic use in cats with hepatobiliary disease. |
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