Assessment of the measurement of canine and feline serum fibroblast growth
factor-23 concentrations by automated chemiluminescence immunoassay |
| |
| Authors: | Hirosumi MIYAKAWA Huai-Hsun HSU Mizuki OGAWA Yuichi MIYAGAWA Naoyuki TAKEMURA |
| |
| Institution: | 1)Laboratory of Veterinary Internal Medicine II, Nippon Veterinary and Life Science University, 1-7-1 Kyonan, Musashino, Tokyo 180-0023, Japan |
| |
| Abstract: | This study compared canine and feline fibroblast growth factor (FGF)-23 concentration measurements between automated chemiluminescence assay (CLEIA) and enzyme-linked immunosorbent assay (ELISA). Seventy serum samples each from dogs and cats were evaluated. FGF-23 measurements by CLEIA significantly correlated with those of ELISA in both dogs and cats. The Bland–Altman test showed that FGF-23 between CLEIA and ELISA had fixed and proportional biases, respectively, in both dogs and cats. Measurements by CLEIA were lower than those of ELISA, especially in higher serum FGF-23 concentrations. This study showed that FGF-23 concentrations in dogs and cats can be evaluated by automated CLEIA. However, FGF-23 cannot be directly compared between CLEIA and ELISA. |
| |
| Keywords: | biomarker cat dog mineral metabolism |
|
|
