| 己烯雌酚半琥珀酸的合成 |
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| 引用本文： | 雷莉辉,曲志娜,刘爽,路平,郑增忍,郭福生,蒋正军,陈德坤.己烯雌酚半琥珀酸的合成[J].动物医学进展,2004,25(2):62-64. |
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| 作者姓名： | 雷莉辉 曲志娜 刘爽 路平 郑增忍 郭福生 蒋正军 陈德坤 |
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| 作者单位： | 西北农林科技大学动物科技学院,陕西杨陵,712100;农业部动物及动物产品卫生质量监督检测测试中心,山东青岛,266032 |
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| 摘 要： | 将己烯雌酚与丁二酸酐按一定比例溶解于无水吡啶中 ,室温下反应 3 4h。反应产物用稀盐酸溶液洗涤 ,将所得沉淀干燥后经分离纯化 ,对纯化产物进行高分辨质谱、红外光谱鉴定。结果表明 ,高分辨质谱测定出纯化物的分子量为 3 86.195 9,红外光谱鉴定出纯化物的官能团和己烯雌酚半琥珀酸相符 ,从而证明所合成的产物就是己烯雌酚半琥珀酸。本研究为己烯雌酚免疫原的合成奠定了基础
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| 关 键 词： | 己烯雌酚 己烯雌酚半琥珀酸 红外光谱 高分辨质谱 |
| 文章编号： | 1007-5038(2004)02-0062-03 |
| 修稿时间： | 2003年9月23日 |
Synthesization of Diethylstilbestrol Hemisuccinate |
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| LEI Li-hui,QU Zhi-na,LIU Shuang,LU Ping,ZHENG Zeng-ren,GUO Fu-sheng,JIANG Zheng-jun,CHEN De-kun.Synthesization of Diethylstilbestrol Hemisuccinate[J].Progress In Veterinary Medicine,2004,25(2):62-64. |
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| Authors: | LEI Li-hui QU Zhi-na LIU Shuang LU Ping ZHENG Zeng-ren GUO Fu-sheng JIANG Zheng-jun CHEN De-kun |
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| Institution: | LEI Li-hui~1,QU Zhi-na~2,LIU Shuang~2,LU Ping~2,ZHENG Zeng-ren~2,GUO Fu-sheng~2,JIANG Zheng-jun~2,CHEN De-kun~1 |
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| Abstract: | To build a method of synthesizing diethylstilbestrol hemisuccinate,diethylstilbestrol was mixed with succinic anhydride according to a certain ratio in dehydrated pyridine. The mixture was stirred at room temperature for 36 h.The residue was washed with dilute hydrochloric acid solution,The precipitation was dried,purified,and identified by the infrared spectrometry (IR) and high mass spectrometry(HRMS)with DES-HS.Its productivity was 46.7%.The condition of synthesizing DES-HS was simple and its productivity was higher,this produced the necessary prerequisition to synthesize DES immunogen. |
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| Keywords: | diethylstilbestrol diethylstilbestrol hemisuccinate IR HRMS |
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