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| 三种乳化剂对疫苗乳液稳定性的影响 | |
| 引用本文： | 黄振华,王永录,李晓明,张永光,方玉珍,蒋守田,潘丽,刘力宽,吕建亮.三种乳化剂对疫苗乳液稳定性的影响[J].甘肃农业大学学报,2008,43(3). |
| 作者姓名： | 黄振华 王永录 李晓明 张永光 方玉珍 蒋守田 潘丽 刘力宽 吕建亮 |
| 作者单位： | 1. 甘肃农业大学动物医学院,甘肃兰州,730070;中国农业科学院兰州兽医研究所,国家家畜疫病病原生物学重点实验室,农业部畜禽病毒学重点实验室,国家口蹄疫参考实验富,甘肃,兰州,730046 2. 中国农业科学院兰州兽医研究所,国家家畜疫病病原生物学重点实验室,农业部畜禽病毒学重点实验室,国家口蹄疫参考实验富,甘肃,兰州,730046 3. 甘肃农业大学动物医学院,甘肃兰州,730070 |
| 基金项目： | 国家科技支撑计划"禽流感等重大动物疫病综合防控技术研究"项目 |
| 摘 要： | 采用正交试验L9(34),对F-188、ELP和TWEEN-80三种乳化剂的复配比例进行了研究.结果表明:F-188∶ELP∶TWEEN-80的比例为1∶3∶3时,疫苗乳液的稳定性最好,黏度较小,乳液颗粒直径皆在0.2μm以下,且粒径均匀.方差分析表明,3种乳化剂对乳液稳定性的影响差异极显著(P<0.01),且ELP、TWEEN-80的乳化效果极显著优于F-188. |
| 关 键 词： | 乳化剂 F-188 ELP TWEEN-80 疫苗乳液 稳定性 |
Effect of poloxamer-188,ELP and Tween-80 on stability of emulsification in vaccine |
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| HUANG Zhen-hua,WANG Yong-lu,LI Xiao-ming,ZHANG Yong-guang,FANG Yu-zhen,JIANG Shou-tian,PAN Li,LIU Li-kuan,LV Jian-liang.Effect of poloxamer-188,ELP and Tween-80 on stability of emulsification in vaccine[J].Journal of Gansu Agricultural University,2008,43(3). | |
| Authors: | HUANG Zhen-hua WANG Yong-lu LI Xiao-ming ZHANG Yong-guang FANG Yu-zhen JIANG Shou-tian PAN Li LIU Li-kuan LV Jian-liang |
| Abstract: | The mixing proportion of poloxamer188(F-188),ELP and Tween-80 was tested by orthogonal experiment.The results showed that the stability and viscosity of vaccine were the best when the ratio of F-188∶ELP∶Tween-80 was 1∶3∶3.The particle diameter was uniformity and smaller 0.2 μm by electronic microscope.It is suggested that three kinds of emulsion have a significant effect on stabilization of vaccine.The emulsification effect of poloxamer188 and ELP showed better than Tween-80. |
| Keywords: | poloxamer188 ELP Tween-80 vaccine emulsification stability |
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