| 中药复方联合西药改善2型糖尿病胰岛素抵抗的Meta分析 |
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| 作者姓名： | 向芬 郑承红 |
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| 作者单位： | 湖北中医药大学, 湖北 武汉 430061,武汉市中医医院, 湖北 武汉 430010 |
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| 摘 要： | 目的 运用统计学Meta分析，对中药复方联合西药改善2型糖尿病胰岛素抵抗的临床疗效进行综合评价。方法 全面检索中药复方联合西药改善2型糖尿病胰岛素抵抗的临床随机试验文献，并按照文献选择标准进行筛选，对使用中药复方联合口服二甲双胍等西药治疗的随机对照试验进行Meta分析。结果 共纳入20篇文献，中药复方联合西药改善2型糖尿病患者的空腹血糖（FPG）、糖化血红蛋白（HbA1C）、胰岛素抵抗指数（HOME-IR）以及胰岛素敏感指数（ISI）的指标均优于西药对照组（P<0.05）。结论 中药复方联合西药改善2型糖尿病胰岛素抵抗的疗效优于西药对照组，但由于入选文献质量偏低，样本量较小，可能影响研究结果的真实性，故需大样本量的临床随机试验研究。
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| 关 键 词： | 胰岛素抵抗 中药复方 Meta分析 随机对照试验 |
| 收稿时间： | 2016/12/16 0:00:00 |
Effects of Compound Traditional Chinese Medicine Combined with Western Medicine on Insulin Resistance in Type 2 Diabetes Mellitus:A Meta-Analysis |
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| Authors: | XIANG Fen and ZHENG Chenghong |
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| Institution: | Hubei University of Chinese Medicine, Wuhan, Hubei 430061, China and Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430010, China |
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| Abstract: | Objective By using the Meta-analysis, the compound traditional Chinese medicine (TCM) combined with Western medicine were applied to improve insulin resistance of type 2 diabetes mellitus (T2DM), and evaluate its clinical efficacy. Methods To retrieve fully the randomized clinical trial that the compound TCM combined with Western medicine were applied to improve insulin resistance of T2DM, and according to the literature selection criteria to filtrate them. Meta-analysis is applied to compare the compound of TCM combined with Western medicine to the western medicine, such as mefformin and so on. Results A total of 20 papers were included, the compound TCM combined with Western medicine in improving fasting blood glucose (FPG), glycosylated hemoglobin (HbA1C), insulin resistance index (HOME-IR) and insulin sensitive index (ISI) in patients with T2DM were better than only using Western medicine (P<0.05). Conclusion The curative effect of the compound TCM combined with Western medicine are better than that of Western medicine control group in improving insulin resistance of T2DM. However, the quality of selected papers are low, and the sample is small, which could affect the authenticity of the study results. We should research large sample of randomized clinical trials. |
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| Keywords: | insulin resistance compound TCM Meta-analysis randomized clinical trial |
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