| 穴位敷贴治疗腹泻型肠易激综合征的系统评价 |
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| 作者姓名： | 张莎 王文 李哲 曹亮 王宗仁 沈舒文 |
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| 作者单位： | 第四军医大学西京医院中医科暨全军中医内科中心, 陕西 西安 710032;陕西中医药大学沈舒文名老中医药专家传承工作室, 陕西 咸阳 712046,第四军医大学西京医院中医科暨全军中医内科中心, 陕西 西安 710032,陕西中医药大学团委, 陕西 咸阳 712046,第四军医大学西京医院中医科暨全军中医内科中心, 陕西 西安 710032,第四军医大学西京医院中医科暨全军中医内科中心, 陕西 西安 710032,陕西中医药大学团委, 陕西 咸阳 712046 |
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| 基金项目： | 中国人民解放军第四军医大学西京医院临床高新技术项目（XJGX15Y38）。 |
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| 摘 要： | 目的 系统评价中医穴位敷贴治疗腹泻型肠易激综合征（IBS-D）的有效性及安全性。方法 检索建库至2016年12月间CNKI、VIP、CBM、SCI、PubMed、Embase、Cochrane 等中英文数据库中采用穴位敷贴治疗IBS-D的临床随机对照试验，并辅以手工检索。按照纳入排除标准筛选文献，RevMan 5.3软件进行系统评价。结果（1）最终纳入11项临床随机对照研究，合计803例患者，其中，穴位敷贴治疗组402例，西药对照组401例；（2）文献方法质量学方面，3分以上文献7篇，文献质量普遍较高；（3）有效性方面，与西医对照组相比，穴位敷贴治疗组临床总有效率的总优势比OR95%CI]为3.29 2.25，4.82]，差异有统计学意义（P<0.05）。其中，穴位使用频次前5位的依次是神阙、中脘、脾俞、足三里及肝俞穴；（4）安全性方面，除1项研究外，其余穴位敷贴治疗组不良反应发生率均低于西药对照组。结论 穴位敷贴可以提高IBS-D临床效果且不良反应少，但仍需更多高质量的多中心、大样本随机对照试验证实。
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| 关 键 词： | 腹泻型肠易激综合征 穴位敷贴 随机对照试验 系统评价 |
| 收稿时间： | 2017/1/6 0:00:00 |
A Systematic Review of Diarrhea-Predominant Irritable Bowel Syndrome with Acupoint Application |
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| Authors: | ZHANG Sh WANG Wen LI Zhe CAO Liang WANG Zongren and SHEN Shuwen |
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| Institution: | Department of Traditional Chinese Medicine, TCM Center of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi''an, Shanxi 710032, China;Shen Shuwen Inheritance Studio of the National Veteran Experts of TCM, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shanxi 712046, China,Department of Traditional Chinese Medicine, TCM Center of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi''an, Shanxi 710032, China,Youth League Committee, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shanxi 712046, China,Department of Traditional Chinese Medicine, TCM Center of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi''an, Shanxi 710032, China,Department of Traditional Chinese Medicine, TCM Center of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi''an, Shanxi 710032, China and Youth League Committee, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shanxi 712046, China |
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| Abstract: | Objective To systemic evaluate the efficacy and safety of Acupoint Application in the treatment of IBS-D. Methods The randomized controlled trials of Acupoint Application in the treatment of IBS-D were retrieved from Chinese and English databases, such as CNKI, VIP, CBM, SCI, PubMed, Embase, Cochrane from the date of establishment to December 2016. Manual retrieval was also employed as necessary. Relevant literatures were selected following inclusion and exclusion criteria and evaluated using RevMan 5.3 software. Results (1) A total number of eleven studies, including 803 patients, were enrolled, 402 patients were received Acupoint Application therapy and 401 patients were received with Western medicine therapy. (2) In the aspect of literature methodology quality, seven articles scored above three, reflecting a relatively high literature selection criteria. (3) Clinical efficacy: In comparison with Western medicine, the clinical efficacy with OR 95% CI] of Acupoint Application therapy group was 3.29 2.25, 4.82], which was statistically significant (P<0.05). Furthermore, the top five frequently used points were Shenque, Zhongwan, Pishu, Zusanli and Ganshu point. (4) Safety: Despite one study favored western medicine therapy, Acupoint Application therapy was well tolerated with manageable adverse effect. Conclusion Acupoint Application cwas effective and safe in treatment of IBS-D. However, more standardized multi center and large scale randomized controlled trials are needed. |
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| Keywords: | diarrhea-predominant irritable bowel syndrome acupoint application randomized controlled trial systematic review |
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