Age-specific seroprevalence of Border disease virus and presence of persistently infected sheep in Basque dairy-sheep flocks |
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| Authors: | Berriatua E Barandika J Aduriz G Atxaerandio R Garrido J García-Pérez A L |
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| Institution: | Sanidad Animal, Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER), Berreaga 1, Derio, Bizkaia 48160, Spain. |
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| Abstract: | Using p125/p80 antibody and antigen-ELISA tests, age-specific seroprevalence and presence of persistently infected (PI) sheep were investigated in six commercial latxa dairy-flocks, housed for variable periods. The flocks all had a recent history of Border disease (BD). Every flock included seropositive sheep and seven 0.5-3-year-old PI sheep were detected in two of four flocks tested. Age-specific antibody patterns differed according to the presence or absence of PI sheep in the flock. In flocks free of PI sheep, seroprevalence was 6-13% in 1-year-old sheep and 42-93% in older sheep. In contrast, seroprevalence was 67-99% in sheep raised with PI sheep for at least 1 year and 29-33% in replacement 0.5-0.6-year-old sheep (including a PI sheep) indicating that Border disease virus (BDV) transmission in Basque dairy-flocks can be relatively slow. Moderate seroprevalence in young replacement sheep should not discourage further testing to detect PI sheep, and our results highlight the risk of failing to achieve "natural vaccination" prior to pregnancy by mixing PI sheep with BDV-unexposed ewes. |
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| Keywords: | Border disease Sheep Pestivirus Age-specific seroprevalence Persistent infection Transmission Control |
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