| 利尿剂乙酰唑胺在玻碳电极上的伏安行为 |
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| 引用本文： | 郑新宇,郑丽辉,张兰.利尿剂乙酰唑胺在玻碳电极上的伏安行为[J].福建农林大学学报(自然科学版),2009,38(1). |
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| 作者姓名： | 郑新宇 郑丽辉 张兰 |
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| 作者单位： | 1. 福建农林大学生命科学学院,福建,福州,350002;福州大学食品安全分析和检测技术教育部重点实验室,福建,福州,350002
2. 福州大学食品安全分析和检测技术教育部重点实验室,福建,福州,350002;福州大学运动科学研究中心,福建,福州,350002 |
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| 基金项目： | 福建省体育局重大专项基金，福建省科技厅国际合作重点项目，福建省自然科学基金，福建农林大学校青年基金 |
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| 摘 要： | 在Britton-Robinson(B-R)缓冲液中,用循环伏安法(CV)、线性扫描伏安法(LSV)和微分脉冲伏安法(DPV)研究了利尿剂乙酰唑胺在玻碳电极(GCE)上的伏安行为.结果表明,在pH6.0的B-R缓冲液中,乙酰唑胺在+1.32 V(vs.SCE)电位处产生一个DPV阳极氧化峰,氧化峰电流与乙酰唑胺浓度在3.00-54.0μmol.L-1范围内呈良好的线性关系,最低检测限为0.450μmol.L-1,从而建立了DPV法定量测定乙酰唑胺的新方法.并初步研究了乙酰唑胺的电化学反应机理.
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| 关 键 词： | 乙酰唑胺 玻碳电极 微分脉冲伏安法(DPV) 反应机理 |
Study on the voltammetric behaviour of acetazolamide at glassy carbon electrode |
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| ZHENG Xin-yu,ZHENG Li-hui,ZHANG Lan.Study on the voltammetric behaviour of acetazolamide at glassy carbon electrode[J].Journal of Fujian Agricultural and Forestry University,2009,38(1). |
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| Authors: | ZHENG Xin-yu ZHENG Li-hui ZHANG Lan |
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| Institution: | 1.School of Life Sciences;Fujian Agriculture and Forestry University;Fuzhou;Fujian 350002;China;2.Ministry of Education Key Laboratory of Analysis and Detection for Food Safety;Fuzhou University;3.The Sport Science Research Center;China |
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| Abstract: | The electrochemical oxidation of acetazolamide at glassy carbon electrode(GCE) has been studied.The acetazolamide was investigated by cyclic voltammetry(CV),linear sweep voltammetry(LSV) and differential pulse voltammetry(DPV),respectively.In the Britton-Robinson buffer(pH 6.0),acetazolamide had a DPV oxidation peak at the potential of +1.32 V(vs.SCE),and the peak current was linearly increased with the concentration of acetazolamide in the range of 3.00-54.0 μmol·L-1,with a detection limit of 0.450 μmol·L-1.Thus,DPV method was developed to detect acetazolamide in synthetic urine and serum samples.The possible mechanism of acetazolamide electrochemical oxidation has been investigated initially. |
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| Keywords: | acetazolamide glassy carbon electrode differential pulse voltammetry mechanism |
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