| 实时荧光定量PCR对犬乳腺肿瘤组织TNFR1基因的定量检测 |
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| 引用本文： | 田海燕,卢英,李晓齐,曹红,郑世军.实时荧光定量PCR对犬乳腺肿瘤组织TNFR1基因的定量检测[J].中国兽医杂志,2011,47(6). |
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| 作者姓名： | 田海燕 卢英 李晓齐 曹红 郑世军 |
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| 作者单位： | 1. 中国农业大学动物医学院,北京,海淀,100193;北京市观赏动物医院,北京,海淀,100027
2. 中国农业大学动物医学院,北京,海淀,100193 |
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| 摘 要： | 乳腺肿瘤是母犬中最为常见的肿瘤,运用实时荧光定量PCR检测了37例犬乳腺肿瘤病例和37份正常乳腺组织.结果表明:犬乳腺肿瘤组织中肿瘤坏死因子受体(TNFR1)的表达量显著低于正常对照组织(P<0.05).该试验结果说明,犬乳腺肿瘤的发生很可能与TNFR1表达降低有关,为深人研究肿瘤形成的分子机理提供了重要参考.
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| 关 键 词： | 犬乳腺肿瘤 死亡受体 TNFR1 |
Detection of tumor necrosis factor-1 in canine mammary tumor tissues by fluorescent real-time polymerase chain reaction (PCR) |
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| TIAN Hai-yan,LU Ying,LI Xiao-qi,CAO Hong,ZHENG Shi-jun.Detection of tumor necrosis factor-1 in canine mammary tumor tissues by fluorescent real-time polymerase chain reaction (PCR)[J].Chinese Journal of Veterinary Medicine,2011,47(6). |
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| Authors: | TIAN Hai-yan LU Ying LI Xiao-qi CAO Hong ZHENG Shi-jun |
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| Institution: | TIAN Hai-yan1,2,LU Ying1,LI Xiao-qi1,CAO Hong1,ZHENG Shi-jun1(1.College of Veterinary Medicine,China Agricultural University,Beijing 100193,China,2.Beijing Guanshang Animal Hospital,Beijing 100027,China) |
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| Abstract: | Canine mammary gland tumors are the most commonly-seen tumors in female dogs.However,nowadays the mechanism underlying the occurrence of mammary gland tumor is largely unknown.To investigate into the association of mammary gland tumors with apoptosis,real-time PCR was employed to examine the mRNA expression of Tumor necrosis factor receptor 1(TNFR1) in the mammary gland tumor samples collected from 37 clinical cases.It was found that the mRNA expression of TNFR1 in tumor tissues was significantly decreased ... |
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| Keywords: | canine mammary gland tumor death receptor TNFR1 |
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