| 3-芳氧基-6-氯(或氟)哒嗪类化合物的合成及除草活性研究 |
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| 引用本文： | 王占平,胡方中,邹小毛,杨秀凤,杨华铮.3-芳氧基-6-氯(或氟)哒嗪类化合物的合成及除草活性研究[J].农药学学报,2004,6(2):15-19. |
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| 作者姓名： | 王占平 胡方中 邹小毛 杨秀凤 杨华铮 |
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| 作者单位： | 1.南开大学 元素有机化学国家重点实验室,元素有机化学研究所,天津 300071 |
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| 基金项目： | 国家自然科学基金资助项目(20172031，20302004). |
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| 摘 要： | 从3,6-二氯哒嗪( Ⅰ) 出发,通过氟代得到3,6-二氟哒嗪( Ⅱ )。将 Ⅰ,Ⅱ 分别与取代苯酚缩合,得到了18个3-芳氧基-6-氯哒嗪( Ⅲ )和12个3-芳氧基-6-氟哒嗪( Ⅳ )。所有目标化合物( Ⅲ,Ⅳ )的结构都经过 1H NMR和元素分析确证,部分化合物经IR确证。初步的生物测定结果表明,目标化合物具有不同程度的除草活性,其中化合物 Ⅲ3、Ⅲ8和Ⅳ2 在100 μg/mL的浓度下对稗草Echinochtoa crus-galli的抑制率分别达到95.7%、96.1%和91.2%。
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| 关 键 词： | 3-芳氧基-6-氯-哒嗪 3-芳氧基-6-氟哒嗪 合成 除草活性 |
| 文章编号： | 1008-7303(2004)02-0015-05 |
| 收稿时间： | 2003/7/24 0:00:00 |
| 修稿时间： | 2003年7月24日 |
Synthesis and Herbicidal Activity of 3-Aryloxy-6-chloro(or fluoro) Pyridazines |
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| WANG Zhan-ping,HU Fang-zhong,ZOU Xiao-mao,YANG Xiu-feng and YANG Hua-zheng.Synthesis and Herbicidal Activity of 3-Aryloxy-6-chloro(or fluoro) Pyridazines[J].Chinese Journal of Pesticide Science,2004,6(2):15-19. |
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| Authors: | WANG Zhan-ping HU Fang-zhong ZOU Xiao-mao YANG Xiu-feng and YANG Hua-zheng |
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| Institution: | 1.State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071,China |
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| Abstract: | 3-Aryloxy-6-chloropyridazines and 3-aryloxy-6-fluoropyridazines were prepared from the condensation of various substituted phenols with starting material 3,6-dichloropyradazine and its fluorinated derivative, 3,6-difluoropyridazine in high yields. All compounds were characterized by 1H NMR and elemental analyses, and some of the compounds were confirmed by IR. Preliminary bioassay indicates that some of the title compounds showed herbicidal activity to some extents against Brassica napus and Echinochloa crus-gall, for example, at 100 μg/mL, the inhibition of compounds Ⅲ3, Ⅲ8 and Ⅳ2 against E. crus-gall are 95.7%, 96.1% and 91.2%, respectively. |
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| Keywords: | 3-aryloxy-6-chloropyradazine 3-aryloxy-6-fluoropyradazine synthesis herbicidal activity |
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