Chemical constituents of Lobelia chinensis |
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| Institution: | 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Department of Natural medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;3. Laboratory of Antiinflammation & Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;4. School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China;1. Faculty of Science, University of Kragujevac, 12 Radoja Domanovi?a, 34000 Kragujevac, Serbia;2. Faculty of Physical Chemistry, University of Belgrade, 12-16 Studentski trg, 11000 Belgrade, Serbia;1. Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam;2. Vietnam Military Medical University, Vietnam |
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| Abstract: | Three new 2, 6-disubstituted piperidine alkaloids (1–3), one new polyacetylene (8), together with eight known compounds (4–7, 9–12) were isolated from the whole plants of Lobelia chinensis. Their structures were elucidated on the basis of spectroscopic data interpretation. The absolute configuration of 1 was established by a convenient Mosher ester procedure in which the sample was treated with MTPA chlorides in deuterated pyridine directly in NMR tube. Cytotoxicities of compounds 1–12 were tested against two human lung cancer cell lines, NCI-H292 and MSTO-211H. Compounds 8 and 9 exhibited moderate cytotoxic activity against the two cancer cell lines with the IC50 values in the range of 9.31–12.36 μM. |
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