| 恩诺沙星和环丙沙星对金葡菌的抗菌后效应及抗菌后亚抑菌浓度效应 |
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| 引用本文： | 刘涤洁,陈杖榴,冯淇辉.恩诺沙星和环丙沙星对金葡菌的抗菌后效应及抗菌后亚抑菌浓度效应[J].中国兽医学报,2002,22(3):276-278. |
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| 作者姓名： | 刘涤洁 陈杖榴 冯淇辉 |
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| 作者单位： | 华南农业大学动物医学系,广东,广州,510642 |
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| 摘 要： | 报告了抗菌后效应 (postantibiotic effect,PAE)、抗菌后亚抑菌浓度效应 (postantibiotic sub- MIC effect,PASME)、亚抑菌浓度效应 (sub- MIC effect,SME)研究的方法学和恩诺沙星、环丙沙星对金葡菌抗菌后效应及抗菌后亚抑菌浓度效应的研究结果。试验表明 :2、4MIC的恩诺沙星对金葡菌的 PAE为 1.0 3、1.5 0 h,1/2、1、2、4MIC的环丙沙星的 PAE为 0 .5 1、0 .88、1.47、1.92 h;1/8、1/4、1/2 MIC的恩诺沙星对经 4MIC药物诱导 1h的金葡菌可产生0 .38、1.15、>12 .31h的 PASME,1/8、1/4、1/2 MIC的环丙沙星的 PASME为 2 .6 9、>10 .17、>13.17h;1/8、1/4、1/2 MIC的恩诺沙星和环丙沙星对金葡菌产生的 SME分别为 0 .40、0 .91、>9.44 h和 0 .42、1.14、>9.0 2 h。上述结果说明 ,PAE、PASME和 SME的大小与药物浓度呈正相关 ,且环丙沙星比恩诺沙星对金葡菌有更长的效应
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| 关 键 词： | 恩诺沙星 环丙沙星 金黄色葡萄球菌 抗菌后效应 抗菌后亚抑菌浓度效应 亚抑菌浓度效应 |
| 文章编号： | 1005-4545(2002)03-0276-03 |
| 修稿时间： | 2001年4月27日 |
Postantibiotic Effect and Postantibiotic sub-MIC Effect of Enrofloxacin and Ciprofloxacin against Staphylococcus aureus |
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| LIU Di-jie,CHEN Zhang-liu,FENG Qi-hui.Postantibiotic Effect and Postantibiotic sub-MIC Effect of Enrofloxacin and Ciprofloxacin against Staphylococcus aureus[J].Chinese Journal of Veterinary Science,2002,22(3):276-278. |
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| Authors: | LIU Di-jie CHEN Zhang-liu FENG Qi-hui |
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| Abstract: | In this study,the methodologies of postantibiotic effects(PAE),postantibiotic sub-MIC effect(PASME) and sub-MIC effect(SME) were established and relevant results of enrofloxacin and ciprofloxacin against Staphylococcus aureus were obtained.At two and four times the MIC,PAEs of enrofloxacin were 1.03 and 1.50 h,and the PAEs of ciprofloxacin at 1/2,1,2 and 4 MIC were 0.51,0.88,1.47 and 1.92 h,respectively.After exposing to the drugs at four times the MIC for 1 hour,the S.aureus suspension continued the exposure to 1/8,1/4 and 1/2 MIC and resulted in average PASMEs of 0.38,1.15 and >12.31 h,respectively,for enrofloxacin and 2.69,>10.17 and >12.31 h,respectively,for ciprofloxacin.The SMEs for enrofloxacin at 1/8,1/4 and 1/2 MIC were 0.40,0.91 and >9.44 h,respectively and for ciprofloxacin 0.42,1.14 and >9.02 h,respectively.The results showed that length of PAE,PASME,and SME of the two drugs were in dose-dependent manner,and ciprofloxacin seemed to exhibit longer effects than enrofloxacin against S.aureus. |
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| Keywords: | enrofloxacin ciprofloxacin Staphylococcus aureus PAE PASME SME |
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