Platelets in equine recurrent airway obstruction |
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| Authors: | Hammond A Bailey S R Marr C M Cunningham F M |
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| Institution: | Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Campus, Hertfordshire AL9 7TA, UK. |
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| Abstract: | Platelets contribute to the pathogenesis of human allergic airway disease. The aim of this study was to compare platelet activating factor (PAF)-induced platelet aggregation and thromboxane (Tx) production, plasma Tx and 5-hydroxytryptamine (5-HT) in ponies with recurrent airway obstruction (RAO), an hypersensitivity to inhaled antigens, and normal ponies, before and after antigen exposure. Plasma 5-HT was significantly higher in ponies with RAO but was not further increased by antigen challenge. There was no difference between PAF-induced platelet aggregation or Tx production, or in plasma Tx before or after challenge. These data suggest there may be a difference between platelet 5-HT uptake in RAO and normal ponies but do not provide evidence of platelet activation following antigen exposure. |
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| Keywords: | Equine platelets Recurrent airway obstruction (RAO) Aggregation Thromboxane |
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