PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells |
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| Authors: | Hasegawa Kiminori Martin Flavius Huang Guangming Tumas Dan Diehl Lauri Chan Andrew C |
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| Institution: | Department of Immunology, Genentech, Inc., One DNA Way, South San Francisco, CA 94080, USA. |
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| Abstract: | Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal na?ve T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function. |
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