| 新城疫病毒F48E8体内诱导鸡胸腺淋巴细胞凋亡的研究 |
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| 引用本文： | 房慧伶,李翔,曾芸,王晓丽,韦英益,兰宗宝.新城疫病毒F48E8体内诱导鸡胸腺淋巴细胞凋亡的研究[J].畜牧与兽医,2007,39(4):17-19. |
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| 作者姓名： | 房慧伶 李翔 曾芸 王晓丽 韦英益 兰宗宝 |
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| 作者单位： | 广西大学动物科学技术学院,广西,南宁,530005 |
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| 基金项目： | 广西自治区自然基金项目（桂科自0640021）. |
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| 摘 要： | 利用光镜、透射电镜、凝胶电泳和原位末端标记技术(TUNEL)对鸡新城疫病毒(NDV)F48E8株在体内诱导鸡胸腺淋巴细胞的凋亡情况进行了观察和检测,以期探讨NDV的致病机制。经NDV感染后,鸡胸腺淋巴细胞呈现典型的凋亡特征,感染组胸腺的淋巴细胞凋亡率显著高于对照组(P<0.01)。结果表明:NDV标准强毒F48E8株可以在体内诱导胸腺淋巴细胞凋亡,由此所致的免疫抑制可能是NDV致病的重要原因。
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| 关 键 词： | 新城疫病毒 胸腺 细胞凋亡 淋巴细胞 |
| 文章编号： | 0529-5130（2007）04-0017-03 |
| 修稿时间： | 2006-06-19 |
Apoptosis of chicken thymus lymphocytes induced by newcastle disease virus F48E8 in vivo |
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| FANG Hui-ling,LI Xiang,ZENG Yun,WANG Xiao-li,WEI Ying-yi,LAN Zhong-bao.Apoptosis of chicken thymus lymphocytes induced by newcastle disease virus F48E8 in vivo[J].Animal Husbandry & Veterinary Medicine,2007,39(4):17-19. |
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| Authors: | FANG Hui-ling LI Xiang ZENG Yun WANG Xiao-li WEI Ying-yi LAN Zhong-bao |
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| Institution: | College of Animal Science and Technology, Guangxi University, Nanning 530005, China |
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| Abstract: | Light microscope,transmission electron microscope,electrophoretic analysis of DNA fragmentation and terminal deoxynucleotidyl transfers(TdT) dUTP nick and labeling(TUNEL) were used to study the apoptosis of chicken thymus lymphocytes induced by Newcastle Disease Virus(NDV) F48E8 in vivo. The results showed that chicken thymus lymphocytes exhibited obvious apoptosis.Moreover the apoptotic index of infected group was significantly higher than that of the control group(P<0.01).It suggested that NDVF48E8 can induce apoptosis of chicken thymus lymphocytes in vivo,which will lead to immunodepression and may be the most important pathogeny. |
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| Keywords: | Newcastle disease virus thymus apoptosis lymphocytes |
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